Chronic energy intake restriction (CEIR) ed the median life span and inhibited autoimmunity development of autoimmune disease in BXSB mice, as has established for mice of several other autoimmune-prone, strains. Whether imposed just after weaning or until manifestations of disease had appeared, CEIR or reversed development of autoimmunity and imcomplex-based renal disease in male BXSB mice. CEIR revented the formation of anti-DNA antibodies and ted the increase in circulating immune complex levels typically observed in male mice of this strain. Moreover, exhibited development of splenomegaly and prevented mal age-associated decline of a number of immunologfunctions, including interleukin 2 production, cell-cytotoxic responses, and mixed lymphocyte reactivobserved improvement in cell-mediated immune rewas attributed largely to the capacity of CEIR to inhibit ment of the splenomegaly that occurs concomitant with lon of a non-T, non-B lymphoid cell population. These emphasize that CEIR, even when imposed relatively life in BXSB mice, can influence expression of autoimes and autoimmune diseases of different genetic origins presumed pathogenetic bases.
|Number of pages||5|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|Publication status||Published - Jan 1 1992|
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