Effects of dietary sesaminol and sesamin on eicosanoid production and immunoglobulin level in rats given ethanol

Michiko Nonaka, Kanae Yamashita, Yoshie Iizuka, Mitsuo Namiki, Michihiro Sugano

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The effects of sesaminol and sesamin on the ethanol-induced modulation of immune indices related to food allergy were examined in rats given a low (10%)-casein diet. Chronic ethanol drinking, at the dietary level of 23% (w/w), significantly increased the plasma IgA and IgM concentrations, irrespective of the presence of 0.1% and 0.2% sesaminol, but the effects disappeared with 0.2% sesamin. A significant IgG-elevating effect of these lignans was also found. In contrast, the concentration of plasma IgE was not influenced by the dietary manipulation. Although ethanol drinking did not influence splenic leukotriene B4 production, sesaminol tended to decrease it dose dependently, while sesamin increased the plasma prostaglandin E2 concentration. These results suggest that sesaminol and sesamin seems to have a diverse effect on the plasma levels of immunoglobulins and eicosanoids.

Original languageEnglish
Pages (from-to)836-839
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume61
Issue number5
DOIs
Publication statusPublished - Jan 1 1997

Fingerprint

Eicosanoids
Immunoglobulins
Rats
Ethanol
Plasmas
Drinking
Allergies
Lignans
Leukotriene B4
Food Hypersensitivity
Nutrition
Caseins
Dinoprostone
Immunoglobulin A
Immunoglobulin E
Immunoglobulin M
Immunoglobulin G
Modulation
Diet
sesaminol

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Effects of dietary sesaminol and sesamin on eicosanoid production and immunoglobulin level in rats given ethanol. / Nonaka, Michiko; Yamashita, Kanae; Iizuka, Yoshie; Namiki, Mitsuo; Sugano, Michihiro.

In: Bioscience, Biotechnology and Biochemistry, Vol. 61, No. 5, 01.01.1997, p. 836-839.

Research output: Contribution to journalArticle

Nonaka, Michiko ; Yamashita, Kanae ; Iizuka, Yoshie ; Namiki, Mitsuo ; Sugano, Michihiro. / Effects of dietary sesaminol and sesamin on eicosanoid production and immunoglobulin level in rats given ethanol. In: Bioscience, Biotechnology and Biochemistry. 1997 ; Vol. 61, No. 5. pp. 836-839.
@article{72ed0d4f1a884b079e480666453e4521,
title = "Effects of dietary sesaminol and sesamin on eicosanoid production and immunoglobulin level in rats given ethanol",
abstract = "The effects of sesaminol and sesamin on the ethanol-induced modulation of immune indices related to food allergy were examined in rats given a low (10{\%})-casein diet. Chronic ethanol drinking, at the dietary level of 23{\%} (w/w), significantly increased the plasma IgA and IgM concentrations, irrespective of the presence of 0.1{\%} and 0.2{\%} sesaminol, but the effects disappeared with 0.2{\%} sesamin. A significant IgG-elevating effect of these lignans was also found. In contrast, the concentration of plasma IgE was not influenced by the dietary manipulation. Although ethanol drinking did not influence splenic leukotriene B4 production, sesaminol tended to decrease it dose dependently, while sesamin increased the plasma prostaglandin E2 concentration. These results suggest that sesaminol and sesamin seems to have a diverse effect on the plasma levels of immunoglobulins and eicosanoids.",
author = "Michiko Nonaka and Kanae Yamashita and Yoshie Iizuka and Mitsuo Namiki and Michihiro Sugano",
year = "1997",
month = "1",
day = "1",
doi = "10.1271/bbb.61.836",
language = "English",
volume = "61",
pages = "836--839",
journal = "Bioscience, Biotechnology and Biochemistry",
issn = "0916-8451",
publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",
number = "5",

}

TY - JOUR

T1 - Effects of dietary sesaminol and sesamin on eicosanoid production and immunoglobulin level in rats given ethanol

AU - Nonaka, Michiko

AU - Yamashita, Kanae

AU - Iizuka, Yoshie

AU - Namiki, Mitsuo

AU - Sugano, Michihiro

PY - 1997/1/1

Y1 - 1997/1/1

N2 - The effects of sesaminol and sesamin on the ethanol-induced modulation of immune indices related to food allergy were examined in rats given a low (10%)-casein diet. Chronic ethanol drinking, at the dietary level of 23% (w/w), significantly increased the plasma IgA and IgM concentrations, irrespective of the presence of 0.1% and 0.2% sesaminol, but the effects disappeared with 0.2% sesamin. A significant IgG-elevating effect of these lignans was also found. In contrast, the concentration of plasma IgE was not influenced by the dietary manipulation. Although ethanol drinking did not influence splenic leukotriene B4 production, sesaminol tended to decrease it dose dependently, while sesamin increased the plasma prostaglandin E2 concentration. These results suggest that sesaminol and sesamin seems to have a diverse effect on the plasma levels of immunoglobulins and eicosanoids.

AB - The effects of sesaminol and sesamin on the ethanol-induced modulation of immune indices related to food allergy were examined in rats given a low (10%)-casein diet. Chronic ethanol drinking, at the dietary level of 23% (w/w), significantly increased the plasma IgA and IgM concentrations, irrespective of the presence of 0.1% and 0.2% sesaminol, but the effects disappeared with 0.2% sesamin. A significant IgG-elevating effect of these lignans was also found. In contrast, the concentration of plasma IgE was not influenced by the dietary manipulation. Although ethanol drinking did not influence splenic leukotriene B4 production, sesaminol tended to decrease it dose dependently, while sesamin increased the plasma prostaglandin E2 concentration. These results suggest that sesaminol and sesamin seems to have a diverse effect on the plasma levels of immunoglobulins and eicosanoids.

UR - http://www.scopus.com/inward/record.url?scp=0031148448&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031148448&partnerID=8YFLogxK

U2 - 10.1271/bbb.61.836

DO - 10.1271/bbb.61.836

M3 - Article

VL - 61

SP - 836

EP - 839

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

SN - 0916-8451

IS - 5

ER -