Effects of dietary sphingolipids on levels of serum and liver lipids in rats

K. Imaizumi, A. Tominaga, M. Sato, M. Sugano

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Sphingosine addition to cultured cells has been shown to provoke divergent physiological reactions. The present study was carried out to determine if dietary sphingolipids, which presumably liberate sphingosine during passage through the intestine, influence serum and liver lipids in rats. Rats were given purified diets containing cholesterol (1%) and sphingolipids (0.5 and 2%, composed mainly of ceramide and sphingomyelin) for 2 weeks. Food intake, body weight gain and liver weight were not affected by the supplementation of sphingolipids. The concentration of triglycerides in the serum, but not in the liver, decreased significantly in sphingolipid fed rats, and the accumulation of esterified cholesterol in the liver, but not in the serum increased, depending on the level of dietary sphingolipids. However, no significant changes were observed in the concentration and proportion of the liver phospholipids at 0.5% supplementation, but significant elevation of liver phospholipids when supplemented at 2% level. Thus, it is suggested that sphingosine derived from the dietary sphingolipids can modify serum and liver lipid metabolism.

Original languageEnglish
Pages (from-to)543-548
Number of pages6
JournalNutrition Research
Volume12
Issue number4-5
DOIs
Publication statusPublished - Jan 1 1992
Externally publishedYes

Fingerprint

Sphingolipids
Lipids
Liver
Sphingosine
Serum
Phospholipids
Cholesterol
Sphingomyelins
Ceramides
Lipid Metabolism
Weight Gain
Intestines
Cultured Cells
Triglycerides
Eating
Body Weight
Diet
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Effects of dietary sphingolipids on levels of serum and liver lipids in rats. / Imaizumi, K.; Tominaga, A.; Sato, M.; Sugano, M.

In: Nutrition Research, Vol. 12, No. 4-5, 01.01.1992, p. 543-548.

Research output: Contribution to journalArticle

Imaizumi, K. ; Tominaga, A. ; Sato, M. ; Sugano, M. / Effects of dietary sphingolipids on levels of serum and liver lipids in rats. In: Nutrition Research. 1992 ; Vol. 12, No. 4-5. pp. 543-548.
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