Effects of dietary Trans-fat on biliary and fecal steroid excretion and serum lipoproteins in rats

Michihiro Sugano, Midori Watanabe, Mitsuko Kohno, Young J. Cho, Takashi Ide

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Rats were fed cholesterol-free or cholesterol-enriched diets containing olive oil or partially hydrogenated corn oil at the 10% level for ca. 30 days (c-18:1, 77.0% in the former diet and c-18:1, 24.7% and t-18:1, 42.5% in the latter). The linoleic acid content of these fat diets was made equivalent (1.7 energy%). After feeding cholesterol-free diets, trans fat compared to cis fat showed(a) no untoward effects on growth parameters, (b) a reduction of serum cholesterol levels without influencing concentrations of serum apolipoproteins A-I, B and E, (c) no effects on the bile flow and the concentration of biliary cholesterol and bile acids, (d) an increasing trend of fecal excretion of neutral and acidic steroids, both in terms of mg/day and mg/g feces, and (e) rather equivocal change in the composition of fecal, but not biliary steroids. Similar response patterns were also observed when cholesterol-enriched diets were fed except for a decrease in serum apo B and an ineffectiveness to increase fecal acidic steroids. Together with the results obtained from experiments simultaneously performed with safflower oil and completely hydrogenated corn oil, it seems that the steroid metabolism can be specificallymodified by the geometry of dietary fats.

Original languageEnglish
Pages (from-to)375-381
Number of pages7
JournalLipids
Volume18
Issue number5
DOIs
Publication statusPublished - May 1 1983

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Dietary Fats
Lipoproteins
Rats
Nutrition
Fats
Steroids
Cholesterol
Serum
Diet
Corn Oil
Safflower Oil
Fat-Restricted Diet
Apolipoprotein A-I
Apolipoproteins B
Apolipoproteins E
Linoleic Acid
Bile Acids and Salts
Metabolism
Feces
Bile

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

Cite this

Effects of dietary Trans-fat on biliary and fecal steroid excretion and serum lipoproteins in rats. / Sugano, Michihiro; Watanabe, Midori; Kohno, Mitsuko; Cho, Young J.; Ide, Takashi.

In: Lipids, Vol. 18, No. 5, 01.05.1983, p. 375-381.

Research output: Contribution to journalArticle

Sugano, Michihiro ; Watanabe, Midori ; Kohno, Mitsuko ; Cho, Young J. ; Ide, Takashi. / Effects of dietary Trans-fat on biliary and fecal steroid excretion and serum lipoproteins in rats. In: Lipids. 1983 ; Vol. 18, No. 5. pp. 375-381.
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