Effects of different corticosteroids on the development of osteonecrosis in rabbits

K. Miyanishi, T. Yamamoto, T. Irisa, goro motomura, S. Jingushi, K. Sueishi, Y. Iwamoto

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Objectives. Osteonecrosis (ON) of the femoral head is a devastating complication occurring in patients receiving corticosteroid treatment. This study examined the effect of three corticosteroids on the development of ON in rabbits. Methods. Thirty-nine rabbits were injected once intramuscularly with either 25 mg/kg prednisolone sodium succinate (PSL; 13 rabbits), 20 mg/kg methylprednisolone acetate (MPSL; 13 rabbits) or 20 mg/kg triamcinolone acetonide (TR; 13 rabbits). Four weeks after corticosteroid injection, the bilateral femora and humeri were examined histopathologically for the presence of ON. Haematological examinations were performed before and after corticosteroid injection. Results. MPSL treatment (17/26 proximal femora, 65%) significantly increased ON incidence in the proximal femora compared with the levels seen after TR (4/26, 15%) or PSL (3/26, 12%) treatment (P < 0.01). Although not significantly increased in comparison with rabbits receiving PSL treatment (1/26 proximal humeri, 4%), ON incidence within the proximal humeri was significantly increased in MPSL-treated rabbits (6/26, 23%) in comparison with those seen in rabbits receiving TR (0/26, 0%) treatment (P < 0.05). Serum levels of cholesterol, triglyceride and free fatty acid were significantly higher 1, 2 and 4 weeks after corticosteroid treatment in rabbits treated with MPSL relative to rabbits receiving TR and rabbits with PSL treatment (P < 0.05). Conclusions. MPSL treatment significantly increased ON incidence in rabbits over levels seen after TR or PSL treatment.

Original languageEnglish
Pages (from-to)332-336
Number of pages5
JournalRheumatology
Volume44
Issue number3
DOIs
Publication statusPublished - Mar 1 2005

Fingerprint

Osteonecrosis
Adrenal Cortex Hormones
Rabbits
Humerus
Femur
Therapeutics
Incidence
Triamcinolone Acetonide
Injections
Thigh
Nonesterified Fatty Acids
Triglycerides
Cholesterol

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Pharmacology (medical)

Cite this

Miyanishi, K., Yamamoto, T., Irisa, T., motomura, G., Jingushi, S., Sueishi, K., & Iwamoto, Y. (2005). Effects of different corticosteroids on the development of osteonecrosis in rabbits. Rheumatology, 44(3), 332-336. https://doi.org/10.1093/rheumatology/keh505

Effects of different corticosteroids on the development of osteonecrosis in rabbits. / Miyanishi, K.; Yamamoto, T.; Irisa, T.; motomura, goro; Jingushi, S.; Sueishi, K.; Iwamoto, Y.

In: Rheumatology, Vol. 44, No. 3, 01.03.2005, p. 332-336.

Research output: Contribution to journalArticle

Miyanishi, K, Yamamoto, T, Irisa, T, motomura, G, Jingushi, S, Sueishi, K & Iwamoto, Y 2005, 'Effects of different corticosteroids on the development of osteonecrosis in rabbits', Rheumatology, vol. 44, no. 3, pp. 332-336. https://doi.org/10.1093/rheumatology/keh505
Miyanishi, K. ; Yamamoto, T. ; Irisa, T. ; motomura, goro ; Jingushi, S. ; Sueishi, K. ; Iwamoto, Y. / Effects of different corticosteroids on the development of osteonecrosis in rabbits. In: Rheumatology. 2005 ; Vol. 44, No. 3. pp. 332-336.
@article{ae934cac5fd34506bed71cb9a459c579,
title = "Effects of different corticosteroids on the development of osteonecrosis in rabbits",
abstract = "Objectives. Osteonecrosis (ON) of the femoral head is a devastating complication occurring in patients receiving corticosteroid treatment. This study examined the effect of three corticosteroids on the development of ON in rabbits. Methods. Thirty-nine rabbits were injected once intramuscularly with either 25 mg/kg prednisolone sodium succinate (PSL; 13 rabbits), 20 mg/kg methylprednisolone acetate (MPSL; 13 rabbits) or 20 mg/kg triamcinolone acetonide (TR; 13 rabbits). Four weeks after corticosteroid injection, the bilateral femora and humeri were examined histopathologically for the presence of ON. Haematological examinations were performed before and after corticosteroid injection. Results. MPSL treatment (17/26 proximal femora, 65{\%}) significantly increased ON incidence in the proximal femora compared with the levels seen after TR (4/26, 15{\%}) or PSL (3/26, 12{\%}) treatment (P < 0.01). Although not significantly increased in comparison with rabbits receiving PSL treatment (1/26 proximal humeri, 4{\%}), ON incidence within the proximal humeri was significantly increased in MPSL-treated rabbits (6/26, 23{\%}) in comparison with those seen in rabbits receiving TR (0/26, 0{\%}) treatment (P < 0.05). Serum levels of cholesterol, triglyceride and free fatty acid were significantly higher 1, 2 and 4 weeks after corticosteroid treatment in rabbits treated with MPSL relative to rabbits receiving TR and rabbits with PSL treatment (P < 0.05). Conclusions. MPSL treatment significantly increased ON incidence in rabbits over levels seen after TR or PSL treatment.",
author = "K. Miyanishi and T. Yamamoto and T. Irisa and goro motomura and S. Jingushi and K. Sueishi and Y. Iwamoto",
year = "2005",
month = "3",
day = "1",
doi = "10.1093/rheumatology/keh505",
language = "English",
volume = "44",
pages = "332--336",
journal = "Rheumatology",
issn = "1462-0324",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Effects of different corticosteroids on the development of osteonecrosis in rabbits

AU - Miyanishi, K.

AU - Yamamoto, T.

AU - Irisa, T.

AU - motomura, goro

AU - Jingushi, S.

AU - Sueishi, K.

AU - Iwamoto, Y.

PY - 2005/3/1

Y1 - 2005/3/1

N2 - Objectives. Osteonecrosis (ON) of the femoral head is a devastating complication occurring in patients receiving corticosteroid treatment. This study examined the effect of three corticosteroids on the development of ON in rabbits. Methods. Thirty-nine rabbits were injected once intramuscularly with either 25 mg/kg prednisolone sodium succinate (PSL; 13 rabbits), 20 mg/kg methylprednisolone acetate (MPSL; 13 rabbits) or 20 mg/kg triamcinolone acetonide (TR; 13 rabbits). Four weeks after corticosteroid injection, the bilateral femora and humeri were examined histopathologically for the presence of ON. Haematological examinations were performed before and after corticosteroid injection. Results. MPSL treatment (17/26 proximal femora, 65%) significantly increased ON incidence in the proximal femora compared with the levels seen after TR (4/26, 15%) or PSL (3/26, 12%) treatment (P < 0.01). Although not significantly increased in comparison with rabbits receiving PSL treatment (1/26 proximal humeri, 4%), ON incidence within the proximal humeri was significantly increased in MPSL-treated rabbits (6/26, 23%) in comparison with those seen in rabbits receiving TR (0/26, 0%) treatment (P < 0.05). Serum levels of cholesterol, triglyceride and free fatty acid were significantly higher 1, 2 and 4 weeks after corticosteroid treatment in rabbits treated with MPSL relative to rabbits receiving TR and rabbits with PSL treatment (P < 0.05). Conclusions. MPSL treatment significantly increased ON incidence in rabbits over levels seen after TR or PSL treatment.

AB - Objectives. Osteonecrosis (ON) of the femoral head is a devastating complication occurring in patients receiving corticosteroid treatment. This study examined the effect of three corticosteroids on the development of ON in rabbits. Methods. Thirty-nine rabbits were injected once intramuscularly with either 25 mg/kg prednisolone sodium succinate (PSL; 13 rabbits), 20 mg/kg methylprednisolone acetate (MPSL; 13 rabbits) or 20 mg/kg triamcinolone acetonide (TR; 13 rabbits). Four weeks after corticosteroid injection, the bilateral femora and humeri were examined histopathologically for the presence of ON. Haematological examinations were performed before and after corticosteroid injection. Results. MPSL treatment (17/26 proximal femora, 65%) significantly increased ON incidence in the proximal femora compared with the levels seen after TR (4/26, 15%) or PSL (3/26, 12%) treatment (P < 0.01). Although not significantly increased in comparison with rabbits receiving PSL treatment (1/26 proximal humeri, 4%), ON incidence within the proximal humeri was significantly increased in MPSL-treated rabbits (6/26, 23%) in comparison with those seen in rabbits receiving TR (0/26, 0%) treatment (P < 0.05). Serum levels of cholesterol, triglyceride and free fatty acid were significantly higher 1, 2 and 4 weeks after corticosteroid treatment in rabbits treated with MPSL relative to rabbits receiving TR and rabbits with PSL treatment (P < 0.05). Conclusions. MPSL treatment significantly increased ON incidence in rabbits over levels seen after TR or PSL treatment.

UR - http://www.scopus.com/inward/record.url?scp=14944342196&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14944342196&partnerID=8YFLogxK

U2 - 10.1093/rheumatology/keh505

DO - 10.1093/rheumatology/keh505

M3 - Article

VL - 44

SP - 332

EP - 336

JO - Rheumatology

JF - Rheumatology

SN - 1462-0324

IS - 3

ER -