TY - JOUR
T1 - Effects of dioxin-related compounds on bone mineral density in patients affected by the Yusho incident
AU - Fukushi, Jun ichi
AU - Tokunaga, Shoji
AU - Nakashima, Yasuharu
AU - Motomura, Goro
AU - Mitoma, Chikage
AU - Uchi, Hiroshi
AU - Furue, Masutaka
AU - Iwamoto, Yukihide
N1 - Funding Information:
This study was supported by a Health and Labour Sciences Research Grant from the Ministry of Health, Labour and Welfare , Japan; Research on Food Safety (project nos: H22-Designated Research-001 and H24-Designated Research-014 ), and JSPS KAKENHI Grant Number 26462301 . We are grateful to Dr. Yoshiko Takao and Dr. Junboku Kajiwara for the measurement of dioxin-related compounds.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Exposure to dioxin-related compounds results in many adverse health effects. Several studies have examined the effects of dioxin-related compounds on human bone metabolism with inconsistent results. In Japan in 1968, accidental human exposure to rice oil contaminated with dioxin-related compounds led to the development of Yusho oil disease. The aim of this study was to determine whether exposure to dioxin-related compounds was associated with bone mineral density in Yusho patients. In 2010, 262 women and 227 men underwent dual-energy X-ray absorptiometry bone scans as part of the nationwide Yusho health examination. Serum levels of polychlorinated dibenzo-p-dioxin, polychlorinated dibenzofurans, and non-ortho polychlorinated biphenyls were measured using high-resolution gas chromatography and high-resolution mass spectrometry. When adjusted for prefecture, 1,2,3,4,7,8-HxCDD and 2,3,7,8-TCDF were significantly positively associated with Z-scores in men. No congeners were positively associated with Z-scores in women. After adjustment for prefecture and body mass index, one congener, 1,2,3,4,6,7,8-HpCDD, was negatively associated with Z-scores in women. In contrast, no congeners remained significant in men after adjusting for body mass index. This may suggest that 1,2,3,4,6,7,8-HpCDD has a negative effect on bone mineral density in women; however, the findings should be interpreted carefully, because no increase in the serum level of this congener was observed in patients with Yusho disease.
AB - Exposure to dioxin-related compounds results in many adverse health effects. Several studies have examined the effects of dioxin-related compounds on human bone metabolism with inconsistent results. In Japan in 1968, accidental human exposure to rice oil contaminated with dioxin-related compounds led to the development of Yusho oil disease. The aim of this study was to determine whether exposure to dioxin-related compounds was associated with bone mineral density in Yusho patients. In 2010, 262 women and 227 men underwent dual-energy X-ray absorptiometry bone scans as part of the nationwide Yusho health examination. Serum levels of polychlorinated dibenzo-p-dioxin, polychlorinated dibenzofurans, and non-ortho polychlorinated biphenyls were measured using high-resolution gas chromatography and high-resolution mass spectrometry. When adjusted for prefecture, 1,2,3,4,7,8-HxCDD and 2,3,7,8-TCDF were significantly positively associated with Z-scores in men. No congeners were positively associated with Z-scores in women. After adjustment for prefecture and body mass index, one congener, 1,2,3,4,6,7,8-HpCDD, was negatively associated with Z-scores in women. In contrast, no congeners remained significant in men after adjusting for body mass index. This may suggest that 1,2,3,4,6,7,8-HpCDD has a negative effect on bone mineral density in women; however, the findings should be interpreted carefully, because no increase in the serum level of this congener was observed in patients with Yusho disease.
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U2 - 10.1016/j.chemosphere.2015.11.091
DO - 10.1016/j.chemosphere.2015.11.091
M3 - Article
C2 - 26650575
AN - SCOPUS:84960192741
VL - 145
SP - 25
EP - 33
JO - Chemosphere
JF - Chemosphere
SN - 0045-6535
ER -