Effects of docosahexaenoic and eicosapentaenoic acid on lipid metabolism, eicosanoid production, platelet aggregation and atherosclerosis in hypercholesterolemic rats

Yosef Adan, Kenichi Shibata, Masao Sato, Ikuo Ikeda, Katsumi Imaizum

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Exogenously hypercholesterolemic (ExHC) rats were fed on an atherogenic diet supplemented with 1% each of either ethyl ester docosahexaenoic acid [EE-DHA, 22:6(n-3)], ethyl ester eicosapentaenoic acid [EE-EPA, 20:5(n-3)] or safflower oil (SO) for 6 months. The rats fed on the diets containing EE-EPA or EE-DHA, compared with those fed on SO, had lower serum cholesterol and triacylglycerol levels, less aggregation of platelets and slower progress of intimal thickening in the ascending aorta. Relative to the SO-fed rats, both of the (n-3) fatty acid-fed rats had a significantly reduced proportion of arachidonic acid in the platelet and aortic phospholipids, and lower production of thromboxane A2 by platelets and of prostacyclin by the aorta. These results suggest that EPA and DHA are similarly involved in preventing atherosclerosis development by reducing hypercholesterolemia and modifying the platelet functions.

Original languageEnglish
Pages (from-to)111-119
Number of pages9
JournalBioscience, Biotechnology and Biochemistry
Volume63
Issue number1
DOIs
Publication statusPublished - Jan 1 1999

Fingerprint

Eicosapentaenoic Acid
Eicosanoids
Docosahexaenoic Acids
Safflower Oil
Platelets
Platelet Aggregation
Lipid Metabolism
Rats
Atherosclerosis
Agglomeration
Blood Platelets
Nutrition
Aorta
Tunica Intima
Atherogenic Diet
Thromboxane A2
Omega-3 Fatty Acids
Epoprostenol
Hypercholesterolemia
Arachidonic Acid

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Effects of docosahexaenoic and eicosapentaenoic acid on lipid metabolism, eicosanoid production, platelet aggregation and atherosclerosis in hypercholesterolemic rats. / Adan, Yosef; Shibata, Kenichi; Sato, Masao; Ikeda, Ikuo; Imaizum, Katsumi.

In: Bioscience, Biotechnology and Biochemistry, Vol. 63, No. 1, 01.01.1999, p. 111-119.

Research output: Contribution to journalArticle

@article{acb1c8ea32d94372b1ebd17547fb1371,
title = "Effects of docosahexaenoic and eicosapentaenoic acid on lipid metabolism, eicosanoid production, platelet aggregation and atherosclerosis in hypercholesterolemic rats",
abstract = "Exogenously hypercholesterolemic (ExHC) rats were fed on an atherogenic diet supplemented with 1{\%} each of either ethyl ester docosahexaenoic acid [EE-DHA, 22:6(n-3)], ethyl ester eicosapentaenoic acid [EE-EPA, 20:5(n-3)] or safflower oil (SO) for 6 months. The rats fed on the diets containing EE-EPA or EE-DHA, compared with those fed on SO, had lower serum cholesterol and triacylglycerol levels, less aggregation of platelets and slower progress of intimal thickening in the ascending aorta. Relative to the SO-fed rats, both of the (n-3) fatty acid-fed rats had a significantly reduced proportion of arachidonic acid in the platelet and aortic phospholipids, and lower production of thromboxane A2 by platelets and of prostacyclin by the aorta. These results suggest that EPA and DHA are similarly involved in preventing atherosclerosis development by reducing hypercholesterolemia and modifying the platelet functions.",
author = "Yosef Adan and Kenichi Shibata and Masao Sato and Ikuo Ikeda and Katsumi Imaizum",
year = "1999",
month = "1",
day = "1",
doi = "10.1271/bbb.63.111",
language = "English",
volume = "63",
pages = "111--119",
journal = "Bioscience, Biotechnology and Biochemistry",
issn = "0916-8451",
publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",
number = "1",

}

TY - JOUR

T1 - Effects of docosahexaenoic and eicosapentaenoic acid on lipid metabolism, eicosanoid production, platelet aggregation and atherosclerosis in hypercholesterolemic rats

AU - Adan, Yosef

AU - Shibata, Kenichi

AU - Sato, Masao

AU - Ikeda, Ikuo

AU - Imaizum, Katsumi

PY - 1999/1/1

Y1 - 1999/1/1

N2 - Exogenously hypercholesterolemic (ExHC) rats were fed on an atherogenic diet supplemented with 1% each of either ethyl ester docosahexaenoic acid [EE-DHA, 22:6(n-3)], ethyl ester eicosapentaenoic acid [EE-EPA, 20:5(n-3)] or safflower oil (SO) for 6 months. The rats fed on the diets containing EE-EPA or EE-DHA, compared with those fed on SO, had lower serum cholesterol and triacylglycerol levels, less aggregation of platelets and slower progress of intimal thickening in the ascending aorta. Relative to the SO-fed rats, both of the (n-3) fatty acid-fed rats had a significantly reduced proportion of arachidonic acid in the platelet and aortic phospholipids, and lower production of thromboxane A2 by platelets and of prostacyclin by the aorta. These results suggest that EPA and DHA are similarly involved in preventing atherosclerosis development by reducing hypercholesterolemia and modifying the platelet functions.

AB - Exogenously hypercholesterolemic (ExHC) rats were fed on an atherogenic diet supplemented with 1% each of either ethyl ester docosahexaenoic acid [EE-DHA, 22:6(n-3)], ethyl ester eicosapentaenoic acid [EE-EPA, 20:5(n-3)] or safflower oil (SO) for 6 months. The rats fed on the diets containing EE-EPA or EE-DHA, compared with those fed on SO, had lower serum cholesterol and triacylglycerol levels, less aggregation of platelets and slower progress of intimal thickening in the ascending aorta. Relative to the SO-fed rats, both of the (n-3) fatty acid-fed rats had a significantly reduced proportion of arachidonic acid in the platelet and aortic phospholipids, and lower production of thromboxane A2 by platelets and of prostacyclin by the aorta. These results suggest that EPA and DHA are similarly involved in preventing atherosclerosis development by reducing hypercholesterolemia and modifying the platelet functions.

UR - http://www.scopus.com/inward/record.url?scp=0032618541&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032618541&partnerID=8YFLogxK

U2 - 10.1271/bbb.63.111

DO - 10.1271/bbb.63.111

M3 - Article

C2 - 10052130

AN - SCOPUS:0032618541

VL - 63

SP - 111

EP - 119

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

SN - 0916-8451

IS - 1

ER -