Effects of EGF and retinoic acid on differentiation of squamous cell carcinoma cells

H. Harada, H. Tashiro, T. Kukita, K. Kurisu

Research output: Contribution to journalArticle

Abstract

Using monoclonal antibody, G6K12, a novel differentiation marker of keratinocyte, we examined the effect of EGF and retinoic acid on the differentiation of SCC-25, a cell line established from human squamous cell carcinoma. EGF inhibited the expression of cell-surface differentiation marker in low cell-density, but not in high cell-density. Retinoic acid (more than 10(-8) M) inhibited the expression of the antigens. The terminal differentiation of SCC-25 cells occurred at the condition of high cell density. These results obtained demonstrate that EGF and retinoic acid inhibit the terminal differentiation of SCC-25 cells, and that the cell density is the important factor for the commitment of the terminal differentiation.

Original languageEnglish
Pages (from-to)655-658
Number of pages4
JournalFukuoka igaku zasshi = Hukuoka acta medica
Volume82
Issue number12
Publication statusPublished - Dec 1991

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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