Abstract
Using monoclonal antibody, G6K12, a novel differentiation marker of keratinocyte, we examined the effect of EGF and retinoic acid on the differentiation of SCC-25, a cell line established from human squamous cell carcinoma. EGF inhibited the expression of cell-surface differentiation marker in low cell-density, but not in high cell-density. Retinoic acid (more than 10(-8) M) inhibited the expression of the antigens. The terminal differentiation of SCC-25 cells occurred at the condition of high cell density. These results obtained demonstrate that EGF and retinoic acid inhibit the terminal differentiation of SCC-25 cells, and that the cell density is the important factor for the commitment of the terminal differentiation.
| Original language | English |
|---|---|
| Pages (from-to) | 655-658 |
| Number of pages | 4 |
| Journal | Fukuoka igaku zasshi = Hukuoka acta medica |
| Volume | 82 |
| Issue number | 12 |
| Publication status | Published - Dec 1991 |
All Science Journal Classification (ASJC) codes
- Medicine(all)