TY - JOUR
T1 - Effects of eradication of Helicobacter pylori on oral malodor and the oral environment
T2 - A single-center observational study
AU - Suzuki, Nao
AU - Beppu, Richiko
AU - Yoneda, Masahiro
AU - Takeshita, Toru
AU - Asakawa, Mikari
AU - Yamashita, Yoshihisa
AU - Hanioka, Takashi
AU - Hirofuji, Takao
AU - Shinohara, Tetsuo
N1 - Funding Information:
This study was supported in part by a Grant-in-Aid for Scientific Research (C) (No. 26463175) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan, and the Oral Medicine Research Center. Neither funding body had role in design of the study and collection, analysis, and interpretation of data and in writing the manuscript.
Publisher Copyright:
© 2020 The Author(s).
PY - 2020/8/28
Y1 - 2020/8/28
N2 - Objective: Although a relationship between Helicobacter pylori and oral malodor has been suggested, it remains to be confirmed. One reason for this is that many studies assess oral malodor subjectively. Another reason for the uncertainty is that the reduction in oral malodor may be due to the effect of antibiotics on the oral microbiota. In this study, changes in oral malodor along with the eradication treatment of H. pylori were investigated by organoleptic test and gas chromatography. In addition, the salivary bacterial composition and clinical parameters were analyzed. Results: The organoleptic test score, hydrogen sulfide and dimethyl sulfide concentrations, and all clinical parameters except for tongue-coating score were significantly decreased at 1 week compared with baseline. Although antibiotic treatment also altered the overall composition of the salivary bacterial population, it had recovered at 7 weeks. On the date that H. pylori was determined to have been eradicated from all of the subjects (7 weeks after treatment), only the organoleptic test score was significantly lower compared with baseline. The hydrogen sulfide and dimethyl sulfide concentrations were non-significantly lower than those at baseline.
AB - Objective: Although a relationship between Helicobacter pylori and oral malodor has been suggested, it remains to be confirmed. One reason for this is that many studies assess oral malodor subjectively. Another reason for the uncertainty is that the reduction in oral malodor may be due to the effect of antibiotics on the oral microbiota. In this study, changes in oral malodor along with the eradication treatment of H. pylori were investigated by organoleptic test and gas chromatography. In addition, the salivary bacterial composition and clinical parameters were analyzed. Results: The organoleptic test score, hydrogen sulfide and dimethyl sulfide concentrations, and all clinical parameters except for tongue-coating score were significantly decreased at 1 week compared with baseline. Although antibiotic treatment also altered the overall composition of the salivary bacterial population, it had recovered at 7 weeks. On the date that H. pylori was determined to have been eradicated from all of the subjects (7 weeks after treatment), only the organoleptic test score was significantly lower compared with baseline. The hydrogen sulfide and dimethyl sulfide concentrations were non-significantly lower than those at baseline.
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U2 - 10.1186/s13104-020-05253-5
DO - 10.1186/s13104-020-05253-5
M3 - Article
C2 - 32859247
AN - SCOPUS:85090170038
VL - 13
JO - BMC Research Notes
JF - BMC Research Notes
SN - 1756-0500
IS - 1
M1 - 406
ER -