TY - JOUR
T1 - Effects of food proteins and peptides on immunoglobulin production in mouse spleen lymphocytes
AU - Okamoto, Takeaki
AU - Yoshimi, Kazuma
AU - Tachibana, Hirofumi
AU - Yamada, Koji
PY - 2003
Y1 - 2003
N2 - We investigated the effects of Casein, whey protein, soybean protein, wheat gluten and their peptides on the proliferation and immunoglobulin (Ig) production of mouse spleen lymphocytes. Among them, bovine β-Casein remarkably enhanced the production of IgA, IgG and IgM. In addition, some peptides from Casein enhanced IgA production and a peptide from wheat gluten enhanced IgA, IgG and IgM production. On the other hand, whey and soybean proteins exerted no immunoregulatory activity, as well as peptides derived from these proteins. β-Casein elevated Ig producing cell population in mouse spleen lymphocytes, but peptides derived from casein did not increase Ig producing cell population. These data suggest that immunoglobulin production stimulating effect of β-Casein takes part in increasing of Ig producing cells. Therefore, Casein and wheat gluten peptides may well be available as immunoregulatory food materials.
AB - We investigated the effects of Casein, whey protein, soybean protein, wheat gluten and their peptides on the proliferation and immunoglobulin (Ig) production of mouse spleen lymphocytes. Among them, bovine β-Casein remarkably enhanced the production of IgA, IgG and IgM. In addition, some peptides from Casein enhanced IgA production and a peptide from wheat gluten enhanced IgA, IgG and IgM production. On the other hand, whey and soybean proteins exerted no immunoregulatory activity, as well as peptides derived from these proteins. β-Casein elevated Ig producing cell population in mouse spleen lymphocytes, but peptides derived from casein did not increase Ig producing cell population. These data suggest that immunoglobulin production stimulating effect of β-Casein takes part in increasing of Ig producing cells. Therefore, Casein and wheat gluten peptides may well be available as immunoregulatory food materials.
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U2 - 10.3136/nskkk.50.72
DO - 10.3136/nskkk.50.72
M3 - Article
AN - SCOPUS:0037225583
SN - 1341-027X
VL - 50
SP - 72
EP - 77
JO - Nippon Shokuhin Kagaku Kogaku Kaishi
JF - Nippon Shokuhin Kagaku Kogaku Kaishi
IS - 2
ER -