Effects of Garcinia cambogia (Hydroxycitric Acid) on Visceral Fat Accumulation: A Double-Blind, Randomized, Placebo-Controlled Trial

Kohsuke Hayamizu, Yuri Ishii, Izuru Kaneko, Manzhen Shen, Yasuhide Okuhara, Norihiro Shigematsu, Hironori Tomi, Mitsuhiro Furuse, Gen Yoshino, Hiroyuki Shimasaki

Research output: Contribution to journalArticle

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Abstract

Background: (-)-Hydroxycitric acid (HCA) is an active ingredient extracted from the rind of the Indian fruit Garcinia cambogia. It inhibits adenosine triphosphate citrate lyase and has been used in the treatment of obesity. Objective: The primary end point of this study was the effects of 12 weeks of G cambogia extract administration on visceral fat accumulation. The secondary end points were body indices (including height, body weight, body mass index [BMI], waist and hip circumference, and waist-hip ratio) and laboratory values (including total cholesterol, triacylglycerol, and free fatty acid). Methods: This study was performed according to a double-blind, randomized, placebo-controlled, parallel-group design. Subjects aged 20 to 65 years with a visceral fat area >90 cm2 were enrolled. Subjects were randomly assigned to receive treatment for 12 weeks with G cambogia (containing 1000 mg of HCA per day) or placebo. At the end of the treatment period, both groups were administered placebo for 4 weeks to assess any rebound effect. Each subject underwent a computed tomography scan at the umbilical level at -2, 0, 12, and 16 weeks. Results: Forty-four subjects were randomized at baseline, and 39 completed the study (G cambogia group, n = 18; placebo group, n = 21). At 16 weeks, the G cambogia group had significantly reduced visceral, subcutaneous, and total fat areas compared with the placebo group (all indices P < 0.001). No severe adverse effect was observed at any time in the test period. There were no significant differences in BMI or body weight at week 12, but there were slight numeric decreases in body weight and BMI in men. There were no signs of a rebound effect from week 12 to week 16. Conclusion: G cambogia reduced abdominal fat accumulation in subjects, regardless of sex, who had the visceral fat accumulation type of obesity. No rebound effect was observed. It is therefore expected that G cambogia may be useful for the prevention and reduction of accumulation of visceral fat.

Original languageEnglish
Pages (from-to)551-567
Number of pages17
JournalCurrent Therapeutic Research - Clinical and Experimental
Volume64
Issue number8
DOIs
Publication statusPublished - Jan 1 2003

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Garcinia cambogia
Garcinia
Intra-Abdominal Fat
Randomized Controlled Trials
Placebos
Body Mass Index
Body Weight
citrate (pro-3S)-lyase
Obesity
Umbilicus
Abdominal Fat
Waist-Hip Ratio
Subcutaneous Fat
Waist Circumference
Nonesterified Fatty Acids
hydroxycitric acid
Hip
Fruit
Triglycerides
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Effects of Garcinia cambogia (Hydroxycitric Acid) on Visceral Fat Accumulation : A Double-Blind, Randomized, Placebo-Controlled Trial. / Hayamizu, Kohsuke; Ishii, Yuri; Kaneko, Izuru; Shen, Manzhen; Okuhara, Yasuhide; Shigematsu, Norihiro; Tomi, Hironori; Furuse, Mitsuhiro; Yoshino, Gen; Shimasaki, Hiroyuki.

In: Current Therapeutic Research - Clinical and Experimental, Vol. 64, No. 8, 01.01.2003, p. 551-567.

Research output: Contribution to journalArticle

Hayamizu, Kohsuke ; Ishii, Yuri ; Kaneko, Izuru ; Shen, Manzhen ; Okuhara, Yasuhide ; Shigematsu, Norihiro ; Tomi, Hironori ; Furuse, Mitsuhiro ; Yoshino, Gen ; Shimasaki, Hiroyuki. / Effects of Garcinia cambogia (Hydroxycitric Acid) on Visceral Fat Accumulation : A Double-Blind, Randomized, Placebo-Controlled Trial. In: Current Therapeutic Research - Clinical and Experimental. 2003 ; Vol. 64, No. 8. pp. 551-567.
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abstract = "Background: (-)-Hydroxycitric acid (HCA) is an active ingredient extracted from the rind of the Indian fruit Garcinia cambogia. It inhibits adenosine triphosphate citrate lyase and has been used in the treatment of obesity. Objective: The primary end point of this study was the effects of 12 weeks of G cambogia extract administration on visceral fat accumulation. The secondary end points were body indices (including height, body weight, body mass index [BMI], waist and hip circumference, and waist-hip ratio) and laboratory values (including total cholesterol, triacylglycerol, and free fatty acid). Methods: This study was performed according to a double-blind, randomized, placebo-controlled, parallel-group design. Subjects aged 20 to 65 years with a visceral fat area >90 cm2 were enrolled. Subjects were randomly assigned to receive treatment for 12 weeks with G cambogia (containing 1000 mg of HCA per day) or placebo. At the end of the treatment period, both groups were administered placebo for 4 weeks to assess any rebound effect. Each subject underwent a computed tomography scan at the umbilical level at -2, 0, 12, and 16 weeks. Results: Forty-four subjects were randomized at baseline, and 39 completed the study (G cambogia group, n = 18; placebo group, n = 21). At 16 weeks, the G cambogia group had significantly reduced visceral, subcutaneous, and total fat areas compared with the placebo group (all indices P < 0.001). No severe adverse effect was observed at any time in the test period. There were no significant differences in BMI or body weight at week 12, but there were slight numeric decreases in body weight and BMI in men. There were no signs of a rebound effect from week 12 to week 16. Conclusion: G cambogia reduced abdominal fat accumulation in subjects, regardless of sex, who had the visceral fat accumulation type of obesity. No rebound effect was observed. It is therefore expected that G cambogia may be useful for the prevention and reduction of accumulation of visceral fat.",
author = "Kohsuke Hayamizu and Yuri Ishii and Izuru Kaneko and Manzhen Shen and Yasuhide Okuhara and Norihiro Shigematsu and Hironori Tomi and Mitsuhiro Furuse and Gen Yoshino and Hiroyuki Shimasaki",
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AU - Kaneko, Izuru

AU - Shen, Manzhen

AU - Okuhara, Yasuhide

AU - Shigematsu, Norihiro

AU - Tomi, Hironori

AU - Furuse, Mitsuhiro

AU - Yoshino, Gen

AU - Shimasaki, Hiroyuki

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