Effects of gene duplication, epistasis, recombination and gene conversion on the fixation time of compensatory mutations

Junko Kusumi, Motoshi Ichinose, Masaru Iizuka

Research output: Contribution to journalArticle

Abstract

Gene duplication is one of the major mechanisms of molecular evolution. Gene duplication enables copies of a gene to accumulate mutations through functional redundancy. If a gene encodes a specific protein that interacts with other proteins, RNA, or DNA, the relaxation of selective constraints caused by gene duplication might contribute to the fixation of compensatory mutations that occur at the interacting sites. In this study, we investigate the effect of gene duplication, epistasis among the duplicated copies and gene conversion on the fixation time of compensatory mutations by extending the original model of compensatory evolution proposed by Kimura in 1985. Our simulation results reveal that the time to fixation of compensatory mutations can be decreased remarkably by gene duplication if one of the duplicated loci can completely mask the deleterious effects of a mutation that occurs at the other locus. Conversely, the fixation time can be increased by gene duplication if such functional compensation is weak. We also show that the combination of the degree of functional compensation and the rate of gene conversion between duplicate loci have contrasting effects on the time to fixation of compensatory mutations.

Original languageEnglish
Pages (from-to)134-141
Number of pages8
JournalJournal of Theoretical Biology
Volume467
DOIs
Publication statusPublished - Apr 21 2019

Fingerprint

Epistasis
Gene Conversion
gene conversion
Gene Duplication
epistasis
Fixation
gene duplication
Duplication
Recombination
Genetic Recombination
Mutation
Genes
Gene
mutation
loci
Locus
Molecular Evolution
Masks
Proteins
Protein

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Cite this

Effects of gene duplication, epistasis, recombination and gene conversion on the fixation time of compensatory mutations. / Kusumi, Junko; Ichinose, Motoshi; Iizuka, Masaru.

In: Journal of Theoretical Biology, Vol. 467, 21.04.2019, p. 134-141.

Research output: Contribution to journalArticle

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