Effects of glutathione and phenobarbital on the toxicity of codeinone

Kunisuke Nagamatsu, Kazuhide Inoue, Tadao Terao, Satoshi Toki

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The ability of sulfhydryl compounds to provide protection against the acute toxicity of codeinone, a toxic metabolite of codeine, was investigated in mice. Subcutaneous administration of codeinone produced a slight reduction in hepatic glutathione concentration. Pretreatment of the mice with glutathione or cysteine significantly increased the survival rate for mice given a lethal dose of codeinone (10 mg/kg). The lethality of codeine was lowered by naloxone, whereas that of codeinone was not blocked by naloxone. The strychnine-like convulsant action of codeinone could be prevented by phenobarbital pretreatment. Glutathione pretreatment reduced the amounts of radioactivity in tissues of mice injected with [N-methyl-3H]codeinone. A possible explanation for these observations is that glutathione reacts in vivo with codeinone and plays a role as a scavenger of this compound. This assumption is supported by the observation that codeinone reacts non-enzymatically with glutathione under physiological conditions.

Original languageEnglish
Pages (from-to)1675-1678
Number of pages4
JournalBiochemical Pharmacology
Volume35
Issue number10
DOIs
Publication statusPublished - May 15 1986
Externally publishedYes

Fingerprint

Phenobarbital
Glutathione
Toxicity
Codeine
Naloxone
Convulsants
Strychnine
6-codeinone
Poisons
Radioactivity
Metabolites
Sulfhydryl Compounds
Cysteine
Tissue
Liver

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Pharmacology

Cite this

Effects of glutathione and phenobarbital on the toxicity of codeinone. / Nagamatsu, Kunisuke; Inoue, Kazuhide; Terao, Tadao; Toki, Satoshi.

In: Biochemical Pharmacology, Vol. 35, No. 10, 15.05.1986, p. 1675-1678.

Research output: Contribution to journalArticle

Nagamatsu, Kunisuke ; Inoue, Kazuhide ; Terao, Tadao ; Toki, Satoshi. / Effects of glutathione and phenobarbital on the toxicity of codeinone. In: Biochemical Pharmacology. 1986 ; Vol. 35, No. 10. pp. 1675-1678.
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