Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese individuals

N. Nishida, J. Ohashi, M. Sugiyama, T. Tsuchiura, K. Yamamoto, K. Hino, M. Honda, S. Kaneko, H. Yatsuhashi, K. Koike, O. Yokosuka, E. Tanaka, A. Taketomi, M. Kurosaki, N. Izumi, N. Sakamoto, Y. Eguchi, Takehiko Sasazuki, K. Tokunaga, M. Mizokami

Research output: Contribution to journalArticle

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Abstract

Significant associations of HLA-DP alleles with chronic hepatitis B (CHB) infection are evident in Asian and Arabian populations, including Japanese, Han Chinese, Korean, and Saudi Arabian populations. Here, significant associations between CHB infection and five DPB1 alleles (two susceptibility alleles, DPB1*05:01 and *09:01, and three protective alleles, DPB1*02:01, *04:01, and *04:02) were confirmed in a population comprising of 2582 Japanese individuals. Furthermore, odds ratios for CHB were higher for those with both DPB1 susceptibility alleles than for those with only one susceptibility allele; therefore, effects of susceptibility alleles were additive for risk of CHB infection. Similarly, protective alleles showed an additive effect on protection from CHB infection. Moreover, heterozygotes of any protective allele showed stronger association with CHB than did homozygotes, suggesting that heterozygotes may bind a greater variety of hepatitis B-derived peptides, and thus present these peptides more efficiently to T-cell receptors than homozygotes. Notably, compound heterozygote of the protective allele (any one of DPB1*02:01, *04:01, and *04:02) and the susceptible allele DPB1*05:01 was significantly associated with protection against CHB infection, which indicates that one protective HLA-DPB1 molecule can provide dominant protection. Identification of the HLA-DPB1 genotypes associated with susceptibility to and protection from CHB infection is essential for future analysis of the mechanisms responsible for immune recognition of hepatitis B virus antigens by HLA-DPB1 molecules.

Original languageEnglish
Pages (from-to)406-412
Number of pages7
JournalTissue antigens
Volume86
Issue number6
DOIs
Publication statusPublished - Dec 1 2015

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Chronic Hepatitis B
Alleles
Genotype
Infection
HLA-DP Antigens
Peptides
Molecules
T-Cell Antigen Receptor
Viruses
Heterozygote
Homozygote
HLA-DPB1 antigen
Population
Hepatitis B Antigens
Hepatitis B
Hepatitis B virus
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

Cite this

Nishida, N., Ohashi, J., Sugiyama, M., Tsuchiura, T., Yamamoto, K., Hino, K., ... Mizokami, M. (2015). Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese individuals. Tissue antigens, 86(6), 406-412. https://doi.org/10.1111/tan.12684

Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese individuals. / Nishida, N.; Ohashi, J.; Sugiyama, M.; Tsuchiura, T.; Yamamoto, K.; Hino, K.; Honda, M.; Kaneko, S.; Yatsuhashi, H.; Koike, K.; Yokosuka, O.; Tanaka, E.; Taketomi, A.; Kurosaki, M.; Izumi, N.; Sakamoto, N.; Eguchi, Y.; Sasazuki, Takehiko; Tokunaga, K.; Mizokami, M.

In: Tissue antigens, Vol. 86, No. 6, 01.12.2015, p. 406-412.

Research output: Contribution to journalArticle

Nishida, N, Ohashi, J, Sugiyama, M, Tsuchiura, T, Yamamoto, K, Hino, K, Honda, M, Kaneko, S, Yatsuhashi, H, Koike, K, Yokosuka, O, Tanaka, E, Taketomi, A, Kurosaki, M, Izumi, N, Sakamoto, N, Eguchi, Y, Sasazuki, T, Tokunaga, K & Mizokami, M 2015, 'Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese individuals', Tissue antigens, vol. 86, no. 6, pp. 406-412. https://doi.org/10.1111/tan.12684
Nishida N, Ohashi J, Sugiyama M, Tsuchiura T, Yamamoto K, Hino K et al. Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese individuals. Tissue antigens. 2015 Dec 1;86(6):406-412. https://doi.org/10.1111/tan.12684
Nishida, N. ; Ohashi, J. ; Sugiyama, M. ; Tsuchiura, T. ; Yamamoto, K. ; Hino, K. ; Honda, M. ; Kaneko, S. ; Yatsuhashi, H. ; Koike, K. ; Yokosuka, O. ; Tanaka, E. ; Taketomi, A. ; Kurosaki, M. ; Izumi, N. ; Sakamoto, N. ; Eguchi, Y. ; Sasazuki, Takehiko ; Tokunaga, K. ; Mizokami, M. / Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese individuals. In: Tissue antigens. 2015 ; Vol. 86, No. 6. pp. 406-412.
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abstract = "Significant associations of HLA-DP alleles with chronic hepatitis B (CHB) infection are evident in Asian and Arabian populations, including Japanese, Han Chinese, Korean, and Saudi Arabian populations. Here, significant associations between CHB infection and five DPB1 alleles (two susceptibility alleles, DPB1*05:01 and *09:01, and three protective alleles, DPB1*02:01, *04:01, and *04:02) were confirmed in a population comprising of 2582 Japanese individuals. Furthermore, odds ratios for CHB were higher for those with both DPB1 susceptibility alleles than for those with only one susceptibility allele; therefore, effects of susceptibility alleles were additive for risk of CHB infection. Similarly, protective alleles showed an additive effect on protection from CHB infection. Moreover, heterozygotes of any protective allele showed stronger association with CHB than did homozygotes, suggesting that heterozygotes may bind a greater variety of hepatitis B-derived peptides, and thus present these peptides more efficiently to T-cell receptors than homozygotes. Notably, compound heterozygote of the protective allele (any one of DPB1*02:01, *04:01, and *04:02) and the susceptible allele DPB1*05:01 was significantly associated with protection against CHB infection, which indicates that one protective HLA-DPB1 molecule can provide dominant protection. Identification of the HLA-DPB1 genotypes associated with susceptibility to and protection from CHB infection is essential for future analysis of the mechanisms responsible for immune recognition of hepatitis B virus antigens by HLA-DPB1 molecules.",
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AU - Ohashi, J.

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AU - Yamamoto, K.

AU - Hino, K.

AU - Honda, M.

AU - Kaneko, S.

AU - Yatsuhashi, H.

AU - Koike, K.

AU - Yokosuka, O.

AU - Tanaka, E.

AU - Taketomi, A.

AU - Kurosaki, M.

AU - Izumi, N.

AU - Sakamoto, N.

AU - Eguchi, Y.

AU - Sasazuki, Takehiko

AU - Tokunaga, K.

AU - Mizokami, M.

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N2 - Significant associations of HLA-DP alleles with chronic hepatitis B (CHB) infection are evident in Asian and Arabian populations, including Japanese, Han Chinese, Korean, and Saudi Arabian populations. Here, significant associations between CHB infection and five DPB1 alleles (two susceptibility alleles, DPB1*05:01 and *09:01, and three protective alleles, DPB1*02:01, *04:01, and *04:02) were confirmed in a population comprising of 2582 Japanese individuals. Furthermore, odds ratios for CHB were higher for those with both DPB1 susceptibility alleles than for those with only one susceptibility allele; therefore, effects of susceptibility alleles were additive for risk of CHB infection. Similarly, protective alleles showed an additive effect on protection from CHB infection. Moreover, heterozygotes of any protective allele showed stronger association with CHB than did homozygotes, suggesting that heterozygotes may bind a greater variety of hepatitis B-derived peptides, and thus present these peptides more efficiently to T-cell receptors than homozygotes. Notably, compound heterozygote of the protective allele (any one of DPB1*02:01, *04:01, and *04:02) and the susceptible allele DPB1*05:01 was significantly associated with protection against CHB infection, which indicates that one protective HLA-DPB1 molecule can provide dominant protection. Identification of the HLA-DPB1 genotypes associated with susceptibility to and protection from CHB infection is essential for future analysis of the mechanisms responsible for immune recognition of hepatitis B virus antigens by HLA-DPB1 molecules.

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