Effects of HLA mismatch on cytomegalovirus reactivation in cord blood transplantation

on behalf of the HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Although human leukocyte antigen (HLA) mismatch is often thought to be associated with a high incidence of cytomegalovirus (CMV) reactivation, it is not clear whether this process is mediated by HLA mismatch or other factors, such as acute graft-versus-host disease (aGVHD). Here we focused on cord blood transplantation (CBT) and examined the effects of HLA mismatch on the incidence of CMV reactivation while minimizing the effects of aGVHD. In a multivariate analysis considering aGVHD as a time-dependent covariate, a significant effect on the incidence of CMV reactivation was noted for HLA disparity (hazard ratio [HR]: 0.54 for 8/8 match compared with 3-allele mismatch) and development of aGVHD (HR: 1.26). Next, in an analysis excluding cases that developed aGVHD, the incidences of CMV reactivation for 8/8 match and 1-allele mismatch were low compared with those for other mismatches. These findings were supported by the multivariate analysis (HR: 0.49 for 8/8 match and 0.64 for 1-allele mismatch compared with 3-allele mismatch). Together, these results suggested that HLA mismatch was involved in CMV reactivation and was associated with high morbidity of opportunistic infection after CBT.

Original languageEnglish
Pages (from-to)1004-1012
Number of pages9
JournalBone Marrow Transplantation
Volume54
Issue number7
DOIs
Publication statusPublished - Jul 1 2019

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Graft vs Host Disease
HLA Antigens
Cytomegalovirus
Fetal Blood
Transplantation
Alleles
Incidence
Multivariate Analysis
Opportunistic Infections
Morbidity

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

Cite this

on behalf of the HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation (2019). Effects of HLA mismatch on cytomegalovirus reactivation in cord blood transplantation. Bone Marrow Transplantation, 54(7), 1004-1012. https://doi.org/10.1038/s41409-018-0369-0

Effects of HLA mismatch on cytomegalovirus reactivation in cord blood transplantation. / on behalf of the HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation.

In: Bone Marrow Transplantation, Vol. 54, No. 7, 01.07.2019, p. 1004-1012.

Research output: Contribution to journalArticle

on behalf of the HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation 2019, 'Effects of HLA mismatch on cytomegalovirus reactivation in cord blood transplantation', Bone Marrow Transplantation, vol. 54, no. 7, pp. 1004-1012. https://doi.org/10.1038/s41409-018-0369-0
on behalf of the HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation. Effects of HLA mismatch on cytomegalovirus reactivation in cord blood transplantation. Bone Marrow Transplantation. 2019 Jul 1;54(7):1004-1012. https://doi.org/10.1038/s41409-018-0369-0
on behalf of the HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation. / Effects of HLA mismatch on cytomegalovirus reactivation in cord blood transplantation. In: Bone Marrow Transplantation. 2019 ; Vol. 54, No. 7. pp. 1004-1012.
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