Effects of hydrothermal treatment with CaCl2 solution on surface property and cell response of titanium implants

Masaharu Nakagawa, L. Zhang, K. Udoh, S. Matsuya, Kunio Ishikawa

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

In order to obtain early and good osteointegration after implantation of a titanium implant in the human body, the surface modified treatments using NaOH or H2O2 etc. were reported. In this study, titanium was hydrothermally treated with CaCl2 solutions at 200°C for 24hr (CaCl2-HT). Scanning electron microscope (SEM) observation clearly showed apatite deposition on the surface of CaCl2 HT treated titanium faster than other chemical treated titanium immersion in simulated body fluid. X-ray photoelectron spectroscopy (XPS) analysis demonstrated that Ti-O-Ca bonding was formed on titanium surface by hydrothermal treatment with CaCl 2 solution. And it was revealed that thickness of TiO2, which was known to play important roles for the formation of bone-like apatite, became approximately three times thicker than as-polished titanium. The amount of initial attached MC3T3-E1 cells on as-polished and NaOH, H2O 2 and this CaCl2 HT treated titanium were almost the same values. After 5 days incubation, the growth rate of MC3T3-E1 cells on CaCl 2-HT treated titanium was significantly higher than that on other chemical treated titanium. The hydrothermal treatment with 10-20 mmol/L CaCl2 solution at 200°C was an effective method for the fabrication of titanium implant with good bioactivity and osteoconductivity.

Original languageEnglish
Pages (from-to)985-991
Number of pages7
JournalJournal of Materials Science: Materials in Medicine
Volume16
Issue number11
DOIs
Publication statusPublished - Nov 1 2005

Fingerprint

Surface Properties
Titanium
Surface properties
Apatites
Apatite
Photoelectron Spectroscopy
Body fluids
Body Fluids
Immersion
Bioactivity
Human Body
Osteogenesis
Bone
Electron microscopes
X ray photoelectron spectroscopy
Observation
Electrons
Scanning
Fabrication

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Effects of hydrothermal treatment with CaCl2 solution on surface property and cell response of titanium implants. / Nakagawa, Masaharu; Zhang, L.; Udoh, K.; Matsuya, S.; Ishikawa, Kunio.

In: Journal of Materials Science: Materials in Medicine, Vol. 16, No. 11, 01.11.2005, p. 985-991.

Research output: Contribution to journalArticle

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