Effects of hypothalamic lesion on pancreatic autonomic nerve activity in the rat

Hironobu Yoshimatsu, Akira Niijima, Yutaka Oomura, Kazutoshi Yamabe, Toshihiko Katafuchi

Research output: Contribution to journalArticle

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Abstract

The effects of hypothalamic lesions and intravenous glucose infusion on the efferent activity of vagal and splanchnic nerves to the pancreas were studied in anesthetized rats. Lesions of the ventromedial hypothalamic (VMH), the dorsomedial hypothalamic (DMH) and the paraventricular (PVN) nuclei increased vagal and reduced splanchnic nerve activity. Lesion of the lateral hypothalamic area (LHA) decreased pancreatic vagal nerve activity, and produced either increased or decreased activity of pancreatic splanchnic nerve. Intravenous glucose infusion increased activity of the vagal nerve and reduced that of the splanchnic nerve. These glucose responses were influenced by hypothalamic lesions only slightly or not at all. The findings suggest that hypothalamic modulation of pancreatic hormone secretion involves both the parasympathetic and sympathetic nervous systems, and provide evidence that not only the VMH and the LHA but also the DMH and the PVN are involved in this mechanism.

Original languageEnglish
Pages (from-to)147-152
Number of pages6
JournalBrain Research
Volume303
Issue number1
DOIs
Publication statusPublished - Jun 11 1984

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Splanchnic Nerves
Autonomic Pathways
Lateral Hypothalamic Area
Intravenous Infusions
Glucose
Dorsomedial Hypothalamic Nucleus
Pancreatic Hormones
Parasympathetic Nervous System
Sympathetic Nervous System
Pancreas

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Yoshimatsu, H., Niijima, A., Oomura, Y., Yamabe, K., & Katafuchi, T. (1984). Effects of hypothalamic lesion on pancreatic autonomic nerve activity in the rat. Brain Research, 303(1), 147-152. https://doi.org/10.1016/0006-8993(84)90222-1

Effects of hypothalamic lesion on pancreatic autonomic nerve activity in the rat. / Yoshimatsu, Hironobu; Niijima, Akira; Oomura, Yutaka; Yamabe, Kazutoshi; Katafuchi, Toshihiko.

In: Brain Research, Vol. 303, No. 1, 11.06.1984, p. 147-152.

Research output: Contribution to journalArticle

Yoshimatsu, H, Niijima, A, Oomura, Y, Yamabe, K & Katafuchi, T 1984, 'Effects of hypothalamic lesion on pancreatic autonomic nerve activity in the rat', Brain Research, vol. 303, no. 1, pp. 147-152. https://doi.org/10.1016/0006-8993(84)90222-1
Yoshimatsu, Hironobu ; Niijima, Akira ; Oomura, Yutaka ; Yamabe, Kazutoshi ; Katafuchi, Toshihiko. / Effects of hypothalamic lesion on pancreatic autonomic nerve activity in the rat. In: Brain Research. 1984 ; Vol. 303, No. 1. pp. 147-152.
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