Effects of hypothermia and hyperthermia on attentional and spatial learning deficits following neonatal hypoxia-ischemic insult in rats

Kenichi Mishima, Tomoaki Ikeda, Tetsuya Yoshikawa, Naoya Aoo, Nobuaki Egashira, Yi X. Xia, Tsuyomu Ikenoue, Katsunori Iwasaki, Michihiro Fujiwara

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

We previously reported that rats exposed to neonatal hypoxic-ischemic (HI) insult showed selective and long-lasting learning and memory impairments in the plus maze, 8-arm radial maze, choice reaction time (CRT) task, and water maze, and that they showed severe brain injury to areas such as parietal cortex, hippocampus, striatum and thalamus. In this study, we examined the effects of hypothermia and hyperthermia on learning and memory deficits following neonatal HI insult. Seven-day-old Wistar rats were subjected to left carotid artery ligation followed by 2h of hypoxia (8% O2/92% N2) under three different temperature conditions: 27°C (hypothermia), 33°C (normothermia) and 37°C (hyperthermia) in temperature-controlled chambers. Hypothermia significantly reduced attentional deficits in the CRT task and spatial learning deficits in the water maze, and protected against severe brain injury in comparison with the control temperature. On the other hand, hyperthermia aggravated the behavioral deficits and brain injury. These outcomes clearly show that temperature regulation during HI insult plays an important role in the induction of behavioral and histological changes following neonatal HI insult in rats.

Original languageEnglish
Pages (from-to)209-217
Number of pages9
JournalBehavioural Brain Research
Volume151
Issue number1-2
DOIs
Publication statusPublished - May 5 2004

Fingerprint

Hypothermia
Fever
Brain Injuries
Temperature
Reaction Time
Learning
Parietal Lobe
Water
Memory Disorders
Thalamus
Carotid Arteries
Ligation
Wistar Rats
Hippocampus
Hypoxia
Spatial Learning

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

Effects of hypothermia and hyperthermia on attentional and spatial learning deficits following neonatal hypoxia-ischemic insult in rats. / Mishima, Kenichi; Ikeda, Tomoaki; Yoshikawa, Tetsuya; Aoo, Naoya; Egashira, Nobuaki; Xia, Yi X.; Ikenoue, Tsuyomu; Iwasaki, Katsunori; Fujiwara, Michihiro.

In: Behavioural Brain Research, Vol. 151, No. 1-2, 05.05.2004, p. 209-217.

Research output: Contribution to journalArticle

Mishima, Kenichi ; Ikeda, Tomoaki ; Yoshikawa, Tetsuya ; Aoo, Naoya ; Egashira, Nobuaki ; Xia, Yi X. ; Ikenoue, Tsuyomu ; Iwasaki, Katsunori ; Fujiwara, Michihiro. / Effects of hypothermia and hyperthermia on attentional and spatial learning deficits following neonatal hypoxia-ischemic insult in rats. In: Behavioural Brain Research. 2004 ; Vol. 151, No. 1-2. pp. 209-217.
@article{55de83dfe81e40ef8f0d4acd3b4ff89e,
title = "Effects of hypothermia and hyperthermia on attentional and spatial learning deficits following neonatal hypoxia-ischemic insult in rats",
abstract = "We previously reported that rats exposed to neonatal hypoxic-ischemic (HI) insult showed selective and long-lasting learning and memory impairments in the plus maze, 8-arm radial maze, choice reaction time (CRT) task, and water maze, and that they showed severe brain injury to areas such as parietal cortex, hippocampus, striatum and thalamus. In this study, we examined the effects of hypothermia and hyperthermia on learning and memory deficits following neonatal HI insult. Seven-day-old Wistar rats were subjected to left carotid artery ligation followed by 2h of hypoxia (8{\%} O2/92{\%} N2) under three different temperature conditions: 27°C (hypothermia), 33°C (normothermia) and 37°C (hyperthermia) in temperature-controlled chambers. Hypothermia significantly reduced attentional deficits in the CRT task and spatial learning deficits in the water maze, and protected against severe brain injury in comparison with the control temperature. On the other hand, hyperthermia aggravated the behavioral deficits and brain injury. These outcomes clearly show that temperature regulation during HI insult plays an important role in the induction of behavioral and histological changes following neonatal HI insult in rats.",
author = "Kenichi Mishima and Tomoaki Ikeda and Tetsuya Yoshikawa and Naoya Aoo and Nobuaki Egashira and Xia, {Yi X.} and Tsuyomu Ikenoue and Katsunori Iwasaki and Michihiro Fujiwara",
year = "2004",
month = "5",
day = "5",
doi = "10.1016/j.bbr.2003.08.018",
language = "English",
volume = "151",
pages = "209--217",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Effects of hypothermia and hyperthermia on attentional and spatial learning deficits following neonatal hypoxia-ischemic insult in rats

AU - Mishima, Kenichi

AU - Ikeda, Tomoaki

AU - Yoshikawa, Tetsuya

AU - Aoo, Naoya

AU - Egashira, Nobuaki

AU - Xia, Yi X.

AU - Ikenoue, Tsuyomu

AU - Iwasaki, Katsunori

AU - Fujiwara, Michihiro

PY - 2004/5/5

Y1 - 2004/5/5

N2 - We previously reported that rats exposed to neonatal hypoxic-ischemic (HI) insult showed selective and long-lasting learning and memory impairments in the plus maze, 8-arm radial maze, choice reaction time (CRT) task, and water maze, and that they showed severe brain injury to areas such as parietal cortex, hippocampus, striatum and thalamus. In this study, we examined the effects of hypothermia and hyperthermia on learning and memory deficits following neonatal HI insult. Seven-day-old Wistar rats were subjected to left carotid artery ligation followed by 2h of hypoxia (8% O2/92% N2) under three different temperature conditions: 27°C (hypothermia), 33°C (normothermia) and 37°C (hyperthermia) in temperature-controlled chambers. Hypothermia significantly reduced attentional deficits in the CRT task and spatial learning deficits in the water maze, and protected against severe brain injury in comparison with the control temperature. On the other hand, hyperthermia aggravated the behavioral deficits and brain injury. These outcomes clearly show that temperature regulation during HI insult plays an important role in the induction of behavioral and histological changes following neonatal HI insult in rats.

AB - We previously reported that rats exposed to neonatal hypoxic-ischemic (HI) insult showed selective and long-lasting learning and memory impairments in the plus maze, 8-arm radial maze, choice reaction time (CRT) task, and water maze, and that they showed severe brain injury to areas such as parietal cortex, hippocampus, striatum and thalamus. In this study, we examined the effects of hypothermia and hyperthermia on learning and memory deficits following neonatal HI insult. Seven-day-old Wistar rats were subjected to left carotid artery ligation followed by 2h of hypoxia (8% O2/92% N2) under three different temperature conditions: 27°C (hypothermia), 33°C (normothermia) and 37°C (hyperthermia) in temperature-controlled chambers. Hypothermia significantly reduced attentional deficits in the CRT task and spatial learning deficits in the water maze, and protected against severe brain injury in comparison with the control temperature. On the other hand, hyperthermia aggravated the behavioral deficits and brain injury. These outcomes clearly show that temperature regulation during HI insult plays an important role in the induction of behavioral and histological changes following neonatal HI insult in rats.

UR - http://www.scopus.com/inward/record.url?scp=8444233688&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=8444233688&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2003.08.018

DO - 10.1016/j.bbr.2003.08.018

M3 - Article

VL - 151

SP - 209

EP - 217

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 1-2

ER -