TY - JOUR
T1 - Effects of IL6 C-634G polymorphism on tooth loss and their interaction with smoking habits
AU - Suma, S.
AU - Naito, M.
AU - Wakai, K.
AU - Sasakabe, T.
AU - Hattori, Y.
AU - Okada, R.
AU - Kawai, S.
AU - Hishida, A.
AU - Morita, E.
AU - Nakagawa, H.
AU - Tamura, T.
AU - Hamajima, N.
N1 - Publisher Copyright:
© 2015 John Wiley & Sons A/S.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Objective: To examine the association between an IL6 (Interleukin-6) polymorphism (C-634G or rs1800796) and tooth loss, and an interaction between the polymorphism and smoking habits for the loss. Material and Methods: Our subjects were 4917 check-up examinees ages 35-69. They reported tooth loss and lifestyle in a questionnaire. We regressed the number of teeth on the IL6 genotype, gender, age, smoking, drinking, diabetes, hypertension, physical activity, energy intake, education, and brushing. We further estimated multivariate-adjusted odds ratios (ORs) for having <20 teeth. Results: Participants with a GG genotype tended to have less teeth than those with CC; β = -0.798 (95% confidence interval [CI] = -1.501--0.096). Subjects with a GG genotype were more likely to have <20 teeth than those with CC; OR was 1.56 (95% CI = 1.08-2.25). Association between current smoking and tooth loss was stronger among those with GG than among those with CC. In a multiple regression analysis, a significant interaction was found between GG genotype and current smoking in the prediction of tooth loss (P = 0.018). Conclusion: The IL6 C-634G polymorphism was significantly associated with tooth loss. Our results suggest greater effects of smoking on tooth loss in GG genotype individuals.
AB - Objective: To examine the association between an IL6 (Interleukin-6) polymorphism (C-634G or rs1800796) and tooth loss, and an interaction between the polymorphism and smoking habits for the loss. Material and Methods: Our subjects were 4917 check-up examinees ages 35-69. They reported tooth loss and lifestyle in a questionnaire. We regressed the number of teeth on the IL6 genotype, gender, age, smoking, drinking, diabetes, hypertension, physical activity, energy intake, education, and brushing. We further estimated multivariate-adjusted odds ratios (ORs) for having <20 teeth. Results: Participants with a GG genotype tended to have less teeth than those with CC; β = -0.798 (95% confidence interval [CI] = -1.501--0.096). Subjects with a GG genotype were more likely to have <20 teeth than those with CC; OR was 1.56 (95% CI = 1.08-2.25). Association between current smoking and tooth loss was stronger among those with GG than among those with CC. In a multiple regression analysis, a significant interaction was found between GG genotype and current smoking in the prediction of tooth loss (P = 0.018). Conclusion: The IL6 C-634G polymorphism was significantly associated with tooth loss. Our results suggest greater effects of smoking on tooth loss in GG genotype individuals.
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U2 - 10.1111/odi.12352
DO - 10.1111/odi.12352
M3 - Article
C2 - 26011111
AN - SCOPUS:84938738042
SN - 1354-523X
VL - 21
SP - 807
EP - 813
JO - Oral Diseases
JF - Oral Diseases
IS - 6
ER -
