Effects of Immunization of Mothers on the Immune Reaction of Their Offspring: Inhibition of Immune Responses of Offspring Caused by Antibody Imported Through the Milk

KUNIO IZUCHI, KAZUTO TANIGUCHI, HISASHI GONDO, HIDEYUKI KAWAUCHI, CHIHARU KUBO, KOUICHI SHIRAKAWA, KIKUO NOMOTO

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4 Citations (Scopus)

Abstract

ABSTRACT: Effects of immunization of pregnant AKR mice with nucleated chicken erythrocytes (CRBC) on immune responses of their offspring were examined. Antigen‐specific reduction of generation of cytotoxicity and plaque forming cells (PFC) was demonstrated in the offspring at 8 weeks after birth, and lasted for 15 weeks. Cross‐fostering experiments and cell transfer experiments showed that such suppression would be induced by antibody contained in the milk of immunized mothers rather than suppressor cells. Activities to enhance opsonization and to mediate antibody‐dependent cell‐mediated cytotoxicity (AI)CC) were demonstrated in the serum of such offspring before challenge with CRBC. Delayed footpad reaction (DFR) was maintained at the normal level in such offspring of immunized mice. 1984 Munksgaard

Original languageEnglish
Pages (from-to)66-71
Number of pages6
JournalAmerican Journal of Reproductive Immunology
Volume5
Issue number2
DOIs
Publication statusPublished - Mar 1984

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

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