Effects of immunization of mothers on the immune reaction of their offspring. II. Significance of enhanced antigen elimination by maternal antibodies on the suppression of the offspring

K. Izuchi, H. Gondo, H. Kawauchi, K. Taniguchi, Chiharu Kubo, K. Nomoto, K. Shirakawa

Research output: Contribution to journalArticle

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Abstract

In the offspring of sheep erythrocyte (SRBC)- or chicken erythrocyte (CRBC)-immunized mothers, generation of cytotoxicity and plaque forming cells (PFC) were suppressed, while delayed-type hypersensitivity (DTH) was not. We performed experiments to analyse the mechanism of this suppression. Antigen specific antibodies, which enhanced opsonization or antibody-dependent cell-mediated cytotoxicity (ADCC), might have a close relation to the suppression. The suppression was weakened by a high-dose of antigen challenge or macrophage blockade with colloidal carbon, while enhanced by macrophage activation with Corynebacterium parvum. In contrast, secondary immune responses in the offspring showed the same amplitude as in normal mice. Therefore, the suppression in the offspring might be a result from the early antigen elimination by enhanced opsonization or ADCC due to passive antibodies. But, generation of memory cells or effector cells of DTH might not be affected in the presence of passively transferred antibodies.

Original languageEnglish
Pages (from-to)41-46
Number of pages6
JournalJournal of Clinical and Laboratory Immunology
Volume16
Issue number1
Publication statusPublished - Apr 17 1985
Externally publishedYes

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Antibody-Dependent Cell Cytotoxicity
Immunization
Mothers
Delayed Hypersensitivity
Antigens
Antibodies
Erythrocytes
Propionibacterium acnes
Macrophage Activation
Chickens
Sheep
Carbon
Macrophages

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Effects of immunization of mothers on the immune reaction of their offspring. II. Significance of enhanced antigen elimination by maternal antibodies on the suppression of the offspring. / Izuchi, K.; Gondo, H.; Kawauchi, H.; Taniguchi, K.; Kubo, Chiharu; Nomoto, K.; Shirakawa, K.

In: Journal of Clinical and Laboratory Immunology, Vol. 16, No. 1, 17.04.1985, p. 41-46.

Research output: Contribution to journalArticle

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