Effects of interferon on circadian changes in blood pressure and heart rate variability in patients with chronic hepatitis

Masayo Fukuhara, Kiyoshi Matsumura, Susumu Ohmori, Toshiro Yanai, Yoriaki Tsubota, Isao Abe, Masatoshi Fujishima

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We have determined the effects of interferon therapy on circadian changes in blood pressure and heart rate variability in normotensive hospitalized patients with chronic active hepatitis. Body temperature and pulse rate increased for the initial few days of interferon therapy without significant change in casual or ambulatory blood pressure. Interferon therapy failed to elicit any significant changes in the power spectrum of R-R intervals. In addition, urinary excretion of norepinephrine did not differ between before and during the therapy. These results suggest that interferon therapy caused transient increases in body temperature and pulse rate, but that it did not change either sympathetic or parasympathetic outflow, or the circadian rhythm of blood pressure and heart rate variability, in normotensive subjects.

Original languageEnglish
Pages (from-to)519-523
Number of pages5
JournalAmerican Journal of Hypertension
Volume12
Issue number5
DOIs
Publication statusPublished - May 1 1999

Fingerprint

Chronic Hepatitis
Interferons
Heart Rate
Blood Pressure
Body Temperature
Therapeutics
Circadian Rhythm
Norepinephrine

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Effects of interferon on circadian changes in blood pressure and heart rate variability in patients with chronic hepatitis. / Fukuhara, Masayo; Matsumura, Kiyoshi; Ohmori, Susumu; Yanai, Toshiro; Tsubota, Yoriaki; Abe, Isao; Fujishima, Masatoshi.

In: American Journal of Hypertension, Vol. 12, No. 5, 01.05.1999, p. 519-523.

Research output: Contribution to journalArticle

Fukuhara, Masayo ; Matsumura, Kiyoshi ; Ohmori, Susumu ; Yanai, Toshiro ; Tsubota, Yoriaki ; Abe, Isao ; Fujishima, Masatoshi. / Effects of interferon on circadian changes in blood pressure and heart rate variability in patients with chronic hepatitis. In: American Journal of Hypertension. 1999 ; Vol. 12, No. 5. pp. 519-523.
@article{d8ab2ff71fc64a70a3bccef400a35a1a,
title = "Effects of interferon on circadian changes in blood pressure and heart rate variability in patients with chronic hepatitis",
abstract = "We have determined the effects of interferon therapy on circadian changes in blood pressure and heart rate variability in normotensive hospitalized patients with chronic active hepatitis. Body temperature and pulse rate increased for the initial few days of interferon therapy without significant change in casual or ambulatory blood pressure. Interferon therapy failed to elicit any significant changes in the power spectrum of R-R intervals. In addition, urinary excretion of norepinephrine did not differ between before and during the therapy. These results suggest that interferon therapy caused transient increases in body temperature and pulse rate, but that it did not change either sympathetic or parasympathetic outflow, or the circadian rhythm of blood pressure and heart rate variability, in normotensive subjects.",
author = "Masayo Fukuhara and Kiyoshi Matsumura and Susumu Ohmori and Toshiro Yanai and Yoriaki Tsubota and Isao Abe and Masatoshi Fujishima",
year = "1999",
month = "5",
day = "1",
doi = "10.1016/S0895-7061(98)00252-0",
language = "English",
volume = "12",
pages = "519--523",
journal = "American Journal of Hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - Effects of interferon on circadian changes in blood pressure and heart rate variability in patients with chronic hepatitis

AU - Fukuhara, Masayo

AU - Matsumura, Kiyoshi

AU - Ohmori, Susumu

AU - Yanai, Toshiro

AU - Tsubota, Yoriaki

AU - Abe, Isao

AU - Fujishima, Masatoshi

PY - 1999/5/1

Y1 - 1999/5/1

N2 - We have determined the effects of interferon therapy on circadian changes in blood pressure and heart rate variability in normotensive hospitalized patients with chronic active hepatitis. Body temperature and pulse rate increased for the initial few days of interferon therapy without significant change in casual or ambulatory blood pressure. Interferon therapy failed to elicit any significant changes in the power spectrum of R-R intervals. In addition, urinary excretion of norepinephrine did not differ between before and during the therapy. These results suggest that interferon therapy caused transient increases in body temperature and pulse rate, but that it did not change either sympathetic or parasympathetic outflow, or the circadian rhythm of blood pressure and heart rate variability, in normotensive subjects.

AB - We have determined the effects of interferon therapy on circadian changes in blood pressure and heart rate variability in normotensive hospitalized patients with chronic active hepatitis. Body temperature and pulse rate increased for the initial few days of interferon therapy without significant change in casual or ambulatory blood pressure. Interferon therapy failed to elicit any significant changes in the power spectrum of R-R intervals. In addition, urinary excretion of norepinephrine did not differ between before and during the therapy. These results suggest that interferon therapy caused transient increases in body temperature and pulse rate, but that it did not change either sympathetic or parasympathetic outflow, or the circadian rhythm of blood pressure and heart rate variability, in normotensive subjects.

UR - http://www.scopus.com/inward/record.url?scp=0032965980&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032965980&partnerID=8YFLogxK

U2 - 10.1016/S0895-7061(98)00252-0

DO - 10.1016/S0895-7061(98)00252-0

M3 - Article

C2 - 10342791

AN - SCOPUS:0032965980

VL - 12

SP - 519

EP - 523

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

IS - 5

ER -