TY - JOUR
T1 - Effects of intravenously administered C-type natriuretic peptide in humans
T2 - Comparison with atrial natriuretic peptide
AU - Igaki, Toshio
AU - Itoh, Hiroshi
AU - Suga, Shin Ichi
AU - Hama, Norio
AU - Ogawa, Yoshihiro
AU - Komatsu, Yasato
AU - Yamashita, Jun
AU - Doi, Kentaro
AU - Chun, Tae Hwa
AU - Nakao, Kazuwa
PY - 1998/3
Y1 - 1998/3
N2 - We have previously reported that C-type natriuretic peptide (CNP), the third member of the natriuretic peptide family, is produced in vascular endothelial cells and suggested that CNP might be a local regulator of vascular tone and growth. To evaluate the biological actions of CNP as compared with human a-trial natriuretic peptide (hANP), we intravenously administered synthetic CNP (0.43 nmol/kg) and α-hANP (0.43 and 0.043 nmol/kg) to healthy humans. The experiments were done on different days in the same five healthy volunteers (31±1 yr old). CNP injection caused a transient but significant decrease in both systolic and diastolic blood pressure (-4.3±1.3, -4.1±1.0 mmHg) with a significant increase in heart rate (+7.6±2.6 bpm), and exerted significant diuretic and natriuretic activities (+130±80%, +160±100% over the basal level). These effects of CNP (0.43 nmol/kg) were comparable to, or less than, those of α-hANP (0.043 nmol/kg). CNP injection also significantly suppressed aldosterone secretion (22% reduction as compared with the basal level). Our results demonstrate that intravenously-administered CNP acts as a natriuretic peptide with less potency than ANP.
AB - We have previously reported that C-type natriuretic peptide (CNP), the third member of the natriuretic peptide family, is produced in vascular endothelial cells and suggested that CNP might be a local regulator of vascular tone and growth. To evaluate the biological actions of CNP as compared with human a-trial natriuretic peptide (hANP), we intravenously administered synthetic CNP (0.43 nmol/kg) and α-hANP (0.43 and 0.043 nmol/kg) to healthy humans. The experiments were done on different days in the same five healthy volunteers (31±1 yr old). CNP injection caused a transient but significant decrease in both systolic and diastolic blood pressure (-4.3±1.3, -4.1±1.0 mmHg) with a significant increase in heart rate (+7.6±2.6 bpm), and exerted significant diuretic and natriuretic activities (+130±80%, +160±100% over the basal level). These effects of CNP (0.43 nmol/kg) were comparable to, or less than, those of α-hANP (0.043 nmol/kg). CNP injection also significantly suppressed aldosterone secretion (22% reduction as compared with the basal level). Our results demonstrate that intravenously-administered CNP acts as a natriuretic peptide with less potency than ANP.
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U2 - 10.1291/hypres.21.7
DO - 10.1291/hypres.21.7
M3 - Review article
C2 - 9582102
AN - SCOPUS:0031957394
SN - 0916-9636
VL - 21
SP - 7
EP - 13
JO - Hypertension Research
JF - Hypertension Research
IS - 1
ER -
