Effects of introduction of α-carboxylate, N-methyl, and N-formyl groups on intramolecular cyclization of o-quinone amines

Density functional theory-based study

Ryo Kishida, Adhitya Gandaryus Saputro, Ryan Lacdao Arevalo, Hideaki Kasai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

o-Quinone amines, which are relevant to various biological processes, can undergo spontaneous intramolecular cyclization (ring closure reaction by amino-terminated hydrocarbon side chain) that deactivates them toward another possible reactions, that is, thiol binding. Density functional theory-based calculation is employed for obtaining the potential energy curves along the CN bond formation in the intramolecular cyclization of various o-quinone amines, viz., dopaminequinone, dopaquinone, N-methyl-dopaminequinone, N-formyl-dopaminequinone, and the corresponding methylene-inserted analogues. The activation barrier is decreased by introduction of α-carboxylate and N-methyl group whereas increased by introduction of N-formyl group. A negative correlation between the activation barriers and the level of highest occupied molecular orbital is pointed out. Furthermore, the methylene-inserted analogues show decreased activation barriers. This is explained by reduction of steric repulsion in the transition state.

Original languageEnglish
Article numbere25445
JournalInternational Journal of Quantum Chemistry
Volume117
Issue number23
DOIs
Publication statusPublished - Dec 5 2017
Externally publishedYes

Fingerprint

Cyclization
quinones
carboxylates
Amines
Density functional theory
amines
Chemical activation
activation
density functional theory
methylene
analogs
Molecular orbitals
Hydrocarbons
Potential energy
Sulfhydryl Compounds
thiols
closures
molecular orbitals
hydrocarbons
potential energy

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

Cite this

Effects of introduction of α-carboxylate, N-methyl, and N-formyl groups on intramolecular cyclization of o-quinone amines : Density functional theory-based study. / Kishida, Ryo; Saputro, Adhitya Gandaryus; Arevalo, Ryan Lacdao; Kasai, Hideaki.

In: International Journal of Quantum Chemistry, Vol. 117, No. 23, e25445, 05.12.2017.

Research output: Contribution to journalArticle

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