Effects of ischemic preconditioning and synchronized coronary venous retroperfusion in an off-pump coronary artery bypass grafting model

N. Hatori, D. Segawa, K. Hinokiyama, T. Kimura, Y. Iizuka, M. Ochi, S. Tanaka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Off-pump coronary artery bypass grafting (CABG) has become a popular procedure. However, temporary occlusion of the target vessel is sometimes a threat to the patients. Although ischemic preconditioning (IP) has been proposed to reduce myocardial injury, its effects remain controversial. The coronary veins represent an alternate route for delivery of therapeutic agents and arterial blood to the acutely ischemic myocardium. The aim of this study was to investigate the protective effect against myocardial ischemia and reperfusion injury of combined IP and synchronized coronary venous retroperfusion (SCVR) in an off-pump CABG model. Twenty-one pigs were assigned to 3 groups of 7 animals. In the control group, the left anterior descending coronary artery (LAD) was occluded for 45 min followed by 2 h of reperfusion using a left intrathoracic artery (LITA) bypass circuit. In the IP group, LAD occlusion was done for 5 min with 15 min of reperfusion, followed by 45 min of LAD occlusion. In the SCVR group, pretreatment before LAD occlusion was the same as in the IP group. Then, SCVR was commenced just after the start of LAD occlusion for 45 min. The percent systolic shortening of ischemic myocardium (measured by sonomicrometry) after reperfusion via the LITA was significantly (p < 0.001) greater in the SCVR group (14.6 ± 3.3%) than in the control group (-1.6 ± 5.6%, 95%CI: -24.3 - -8.1) or the IP group (0.7 ± 8.0%, 95%CI: -22.0 - -5.8) after 30 min of reperfusion, and this difference persisted throughout the reperfusion period. Infarct size (expressed as a percentage of the area at risk) was significantly (p < 0.001) smaller in the SCVR group (2.4 ± 2.7%) than in the control group (83.0 ± 2.3%, 95%CI: -99.0 - -62.4) or the IP group (42.0 ± 23.0%, 95%CI: -58.0 - -21.3). Combined SCVR and IP had a potent myocardial protective effect in the present offpump CABG model. This method may be clinically feasible and may be able to prolong a safe coronary occlusion.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalArtificial Organs
Volume25
Issue number1
DOIs
Publication statusPublished - Jan 1 2001

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Off-Pump Coronary Artery Bypass
Ischemic Preconditioning
Coronary Artery Bypass
Pumps
Reperfusion
Animals
Blood
Control Groups
Coronary Vessels
Myocardium
Arteries
Networks (circuits)
Myocardial Reperfusion Injury
Coronary Occlusion
Reperfusion Injury
Myocardial Ischemia
Swine
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

Cite this

Effects of ischemic preconditioning and synchronized coronary venous retroperfusion in an off-pump coronary artery bypass grafting model. / Hatori, N.; Segawa, D.; Hinokiyama, K.; Kimura, T.; Iizuka, Y.; Ochi, M.; Tanaka, S.

In: Artificial Organs, Vol. 25, No. 1, 01.01.2001, p. 47-52.

Research output: Contribution to journalArticle

Hatori, N. ; Segawa, D. ; Hinokiyama, K. ; Kimura, T. ; Iizuka, Y. ; Ochi, M. ; Tanaka, S. / Effects of ischemic preconditioning and synchronized coronary venous retroperfusion in an off-pump coronary artery bypass grafting model. In: Artificial Organs. 2001 ; Vol. 25, No. 1. pp. 47-52.
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AU - Ochi, M.

AU - Tanaka, S.

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N2 - Off-pump coronary artery bypass grafting (CABG) has become a popular procedure. However, temporary occlusion of the target vessel is sometimes a threat to the patients. Although ischemic preconditioning (IP) has been proposed to reduce myocardial injury, its effects remain controversial. The coronary veins represent an alternate route for delivery of therapeutic agents and arterial blood to the acutely ischemic myocardium. The aim of this study was to investigate the protective effect against myocardial ischemia and reperfusion injury of combined IP and synchronized coronary venous retroperfusion (SCVR) in an off-pump CABG model. Twenty-one pigs were assigned to 3 groups of 7 animals. In the control group, the left anterior descending coronary artery (LAD) was occluded for 45 min followed by 2 h of reperfusion using a left intrathoracic artery (LITA) bypass circuit. In the IP group, LAD occlusion was done for 5 min with 15 min of reperfusion, followed by 45 min of LAD occlusion. In the SCVR group, pretreatment before LAD occlusion was the same as in the IP group. Then, SCVR was commenced just after the start of LAD occlusion for 45 min. The percent systolic shortening of ischemic myocardium (measured by sonomicrometry) after reperfusion via the LITA was significantly (p < 0.001) greater in the SCVR group (14.6 ± 3.3%) than in the control group (-1.6 ± 5.6%, 95%CI: -24.3 - -8.1) or the IP group (0.7 ± 8.0%, 95%CI: -22.0 - -5.8) after 30 min of reperfusion, and this difference persisted throughout the reperfusion period. Infarct size (expressed as a percentage of the area at risk) was significantly (p < 0.001) smaller in the SCVR group (2.4 ± 2.7%) than in the control group (83.0 ± 2.3%, 95%CI: -99.0 - -62.4) or the IP group (42.0 ± 23.0%, 95%CI: -58.0 - -21.3). Combined SCVR and IP had a potent myocardial protective effect in the present offpump CABG model. This method may be clinically feasible and may be able to prolong a safe coronary occlusion.

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