Effects of KN-62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, on long-term potentiation in the rat hippocampus

Isao Ito, Hiroyoshi Hidaka, Hiroyuki Sugiyama

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111 Citations (Scopus)

Abstract

Effects of KN-62 (1-[NO-bis-1,5-isoquinolinesulfonyl]-N-methyl-l-tyrosyl-4-phenylpiperazine), a specific inhibitor of calcium/calmodulin-dependent protein kinase II, were examined using rat hippocampus slices in vitro. The inhibitor, when applied in bathing solutions prior to and present during the tetanic stimulations, blocked the generation of long-term potentiation (LTP) in CA1 regions without affecting basal synaptic transmission itself, suggesting an important role of this kinase in the molecular mechanism of CA1 LTP. In contrast, mossy fiber LTP in CA3 regions was not affected significantly by the inhibitor.

Original languageEnglish
Pages (from-to)119-121
Number of pages3
JournalNeuroscience Letters
Volume121
Issue number1-2
DOIs
Publication statusPublished - Jan 2 1991

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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