Effects of L-arginine supplementation on endothelium-dependent coronary vasodilation in patients with angina pectoris and normal coronary arteriograms

Kensuke Egashira, Yoshitaka Hirooka, Takeshi Kuga, Masahiro Mohri, Akira Takeshita

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

Background: The pathogenesis of impaired endothelium-dependent coronary vasodilation in angina pectoris and normal coronary arteriograms (microvascular angina pectoris) is not known. We examined whether supplementation with L-arginine, a precursor of endothelium-derived nitric oxide, improves endothelium-dependent coronary vasodilation in patients with microvascular angina. Methods and Results: The effect of intracoronary infusion of L-arginine (50 mg/min) on acetylcholine-induced coronary vasomotion was studied in eight patients with microvascular angina and eight control subjects. The responses of the large epicardial coronary artery diameter and coronary blood flow were measured with coronary arteriography and an intracoronary Doppler catheter, respectively. Acetylcholine increased coronary blood flow with modest vasoconstriction of the large coronary artery without altering arterial pressure and heart rate. The acetylcholine-induced increases in coronary blood flow were significantly less (P < .01) in patients than in control subjects. L-Arginine significantly augmented the coronary blood flow responses to acetylcholine in patients, but not in control subjects. L-Arginine did not alter responses of the large coronary artery in either group. Conclusions: Study results suggest that L-arginine improved endothelium-dependent vasodilation of coronary microcirculation in patients with microvascular angina pectoris.

Original languageEnglish
Pages (from-to)130-134
Number of pages5
JournalCirculation
Volume94
Issue number2
DOIs
Publication statusPublished - Jan 1 1996

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Microvascular Angina
Vasodilation
Endothelium
Arginine
Acetylcholine
Angina Pectoris
Coronary Vessels
Microcirculation
Vasoconstriction
Angiography
Arterial Pressure
Nitric Oxide
Catheters
Heart Rate

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Effects of L-arginine supplementation on endothelium-dependent coronary vasodilation in patients with angina pectoris and normal coronary arteriograms. / Egashira, Kensuke; Hirooka, Yoshitaka; Kuga, Takeshi; Mohri, Masahiro; Takeshita, Akira.

In: Circulation, Vol. 94, No. 2, 01.01.1996, p. 130-134.

Research output: Contribution to journalArticle

Egashira, Kensuke ; Hirooka, Yoshitaka ; Kuga, Takeshi ; Mohri, Masahiro ; Takeshita, Akira. / Effects of L-arginine supplementation on endothelium-dependent coronary vasodilation in patients with angina pectoris and normal coronary arteriograms. In: Circulation. 1996 ; Vol. 94, No. 2. pp. 130-134.
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