Effects of L-NMMA and L-NNA on the selective ATP-induced enhancement of intratumoral blood flow

Y. Natori, M. Moriguchi, S. Fujiwara, I. Takeshita, M. Fukui, T. Iwaki, H. Kanaide

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Abstract

We studied the effects of NG-monomethyl-L-arginine (L-NMMA) and Nω-nitro-L-arginine (L-NNA) on the selective ATP and adenosine-induced enhancement of intratumoral blood flow in rats measured by the hydrogen clearance method. Both adenosine and ATP produced a selective enhancement of the intratumoral blood flow. Neither L-NMMA nor L-NNA had a significant effect on either the CBF or the intratumoral blood flow. Adenosine-induced enhancement was not inhibited by L-NMMA or L-NNA. On the other hand, the ATP induced enhancement was totally inhibited by both L-NMMA and L-NNA. The inhibitory action of L-NMMA against ATP was blocked by L-arginine, but not by D-arginine. It is suggested that the ATP-induced increase of intratumoral blood flow is evoked by nitric oxide synthesized from the endothelium of the intratumoral blood vessels.

Original languageEnglish
Pages (from-to)120-127
Number of pages8
JournalJournal of Cerebral Blood Flow and Metabolism
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 1 1992
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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