Effects of lipid composition on entrapment of proteins into phosphatidylglycerol-containing liposomes

Sunao Murakami, Tetsuya Fujita, Tsutomu Ono, Shinji Sakai, Hiroyuki Ijima, Koei Kawakami

Research output: Contribution to journalArticlepeer-review

Abstract

Liposomes composed of phosphatidylcholine (PC) and phosphatidylglycerol (PG) were prepared to examine the effects of lipid composition on surface properties of the liposomes and entrapment efficiency of proteins into the liposomes. Lipid composition was found to influence the amount and mode of proteins entrapped into the PC/PG liposomes, as well as the surface properties of the liposomes. Both electrostatic and non-electrostatic interactions between protein and liposome played important roles in the entrapment of protein into the PC-containing liposomes, and the amount of proteins adsorbed electrostatically on the PG-containing liposomes was also influenced by lipid composition.

Original languageEnglish
Pages (from-to)514-517
Number of pages4
Journalkagaku kogaku ronbunshu
Volume32
Issue number6
DOIs
Publication statusPublished - Dec 1 2006

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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