Effects of lotus root (the edible rhizome of nelumbo nucifera) on the deveolopment of non-alcoholic fatty liver disease in obese diabetic db/db mice

Yumi Tsuruta, Koji Nagao, Bungo Shirouchi, Saori Nomura, Keisuke Tsuge, Kazuyoshi Koganemaru, Teruyoshi Yanagita

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Non-alcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease in industrialized countries. The discovery of food components that would ameliorate NAFLD is therefore of interest. Lotus root, the edible rhizome of Nelumbo nucifera, contains a high level of polyphenolic compounds, and several healthpromoting properties of lotus root have been reported. The present study examines whether dietary lotus root powder can protect db/db mice from hepatic injury. After 3 weeks of feeding, the hepatomegaly, hepatic triglyceride accumulation, and elevated hepatic injury markers in the serum were markedly alleviated in the Lotus diet-fed db/db mice relative to the control mice. These effects were partly attributable to suppression of the lipogenic enzyme activities and mRNA expression by the Lotus diet. The serum levels of adiponectin, which has been reported to have a protective effect against NAFLD, were significantly higher in the Lotus group than in the Control group of the db/db mice. Moreover, the hepatic expression of such inflammatory genes as tumor necrosis factor-alpha and monocyte chemoattractant protein-1 were markedly suppressed by the Lotus diet. We speculate that the development and progression of NAFLD were prevented by suppressing the expression of lipogenic and inflammatory genes as a result of the higher serum adioponectin level in the Lotus diet-fed db/db mice.

Original languageEnglish
Pages (from-to)462-466
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume76
Issue number3
DOIs
Publication statusPublished - Apr 2 2012
Externally publishedYes

Fingerprint

Nelumbo
Rhizome
Liver
Nutrition
Diet
Polyphenolic compounds
Genes
Hepatomegaly
Chemokine CCL2
Adiponectin
Wounds and Injuries
Enzyme activity
Serum
Developed Countries
Powders
Liver Diseases
Triglycerides
Tumor Necrosis Factor-alpha
Biomarkers
Non-alcoholic Fatty Liver Disease

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Effects of lotus root (the edible rhizome of nelumbo nucifera) on the deveolopment of non-alcoholic fatty liver disease in obese diabetic db/db mice. / Tsuruta, Yumi; Nagao, Koji; Shirouchi, Bungo; Nomura, Saori; Tsuge, Keisuke; Koganemaru, Kazuyoshi; Yanagita, Teruyoshi.

In: Bioscience, Biotechnology and Biochemistry, Vol. 76, No. 3, 02.04.2012, p. 462-466.

Research output: Contribution to journalArticle

Tsuruta, Yumi ; Nagao, Koji ; Shirouchi, Bungo ; Nomura, Saori ; Tsuge, Keisuke ; Koganemaru, Kazuyoshi ; Yanagita, Teruyoshi. / Effects of lotus root (the edible rhizome of nelumbo nucifera) on the deveolopment of non-alcoholic fatty liver disease in obese diabetic db/db mice. In: Bioscience, Biotechnology and Biochemistry. 2012 ; Vol. 76, No. 3. pp. 462-466.
@article{9e78fbb4c0934aa698a2a41b55303d7a,
title = "Effects of lotus root (the edible rhizome of nelumbo nucifera) on the deveolopment of non-alcoholic fatty liver disease in obese diabetic db/db mice",
abstract = "Non-alcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease in industrialized countries. The discovery of food components that would ameliorate NAFLD is therefore of interest. Lotus root, the edible rhizome of Nelumbo nucifera, contains a high level of polyphenolic compounds, and several healthpromoting properties of lotus root have been reported. The present study examines whether dietary lotus root powder can protect db/db mice from hepatic injury. After 3 weeks of feeding, the hepatomegaly, hepatic triglyceride accumulation, and elevated hepatic injury markers in the serum were markedly alleviated in the Lotus diet-fed db/db mice relative to the control mice. These effects were partly attributable to suppression of the lipogenic enzyme activities and mRNA expression by the Lotus diet. The serum levels of adiponectin, which has been reported to have a protective effect against NAFLD, were significantly higher in the Lotus group than in the Control group of the db/db mice. Moreover, the hepatic expression of such inflammatory genes as tumor necrosis factor-alpha and monocyte chemoattractant protein-1 were markedly suppressed by the Lotus diet. We speculate that the development and progression of NAFLD were prevented by suppressing the expression of lipogenic and inflammatory genes as a result of the higher serum adioponectin level in the Lotus diet-fed db/db mice.",
author = "Yumi Tsuruta and Koji Nagao and Bungo Shirouchi and Saori Nomura and Keisuke Tsuge and Kazuyoshi Koganemaru and Teruyoshi Yanagita",
year = "2012",
month = "4",
day = "2",
doi = "10.1271/bbb.110745",
language = "English",
volume = "76",
pages = "462--466",
journal = "Bioscience, Biotechnology and Biochemistry",
issn = "0916-8451",
publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",
number = "3",

}

TY - JOUR

T1 - Effects of lotus root (the edible rhizome of nelumbo nucifera) on the deveolopment of non-alcoholic fatty liver disease in obese diabetic db/db mice

AU - Tsuruta, Yumi

AU - Nagao, Koji

AU - Shirouchi, Bungo

AU - Nomura, Saori

AU - Tsuge, Keisuke

AU - Koganemaru, Kazuyoshi

AU - Yanagita, Teruyoshi

PY - 2012/4/2

Y1 - 2012/4/2

N2 - Non-alcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease in industrialized countries. The discovery of food components that would ameliorate NAFLD is therefore of interest. Lotus root, the edible rhizome of Nelumbo nucifera, contains a high level of polyphenolic compounds, and several healthpromoting properties of lotus root have been reported. The present study examines whether dietary lotus root powder can protect db/db mice from hepatic injury. After 3 weeks of feeding, the hepatomegaly, hepatic triglyceride accumulation, and elevated hepatic injury markers in the serum were markedly alleviated in the Lotus diet-fed db/db mice relative to the control mice. These effects were partly attributable to suppression of the lipogenic enzyme activities and mRNA expression by the Lotus diet. The serum levels of adiponectin, which has been reported to have a protective effect against NAFLD, were significantly higher in the Lotus group than in the Control group of the db/db mice. Moreover, the hepatic expression of such inflammatory genes as tumor necrosis factor-alpha and monocyte chemoattractant protein-1 were markedly suppressed by the Lotus diet. We speculate that the development and progression of NAFLD were prevented by suppressing the expression of lipogenic and inflammatory genes as a result of the higher serum adioponectin level in the Lotus diet-fed db/db mice.

AB - Non-alcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease in industrialized countries. The discovery of food components that would ameliorate NAFLD is therefore of interest. Lotus root, the edible rhizome of Nelumbo nucifera, contains a high level of polyphenolic compounds, and several healthpromoting properties of lotus root have been reported. The present study examines whether dietary lotus root powder can protect db/db mice from hepatic injury. After 3 weeks of feeding, the hepatomegaly, hepatic triglyceride accumulation, and elevated hepatic injury markers in the serum were markedly alleviated in the Lotus diet-fed db/db mice relative to the control mice. These effects were partly attributable to suppression of the lipogenic enzyme activities and mRNA expression by the Lotus diet. The serum levels of adiponectin, which has been reported to have a protective effect against NAFLD, were significantly higher in the Lotus group than in the Control group of the db/db mice. Moreover, the hepatic expression of such inflammatory genes as tumor necrosis factor-alpha and monocyte chemoattractant protein-1 were markedly suppressed by the Lotus diet. We speculate that the development and progression of NAFLD were prevented by suppressing the expression of lipogenic and inflammatory genes as a result of the higher serum adioponectin level in the Lotus diet-fed db/db mice.

UR - http://www.scopus.com/inward/record.url?scp=84859011499&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859011499&partnerID=8YFLogxK

U2 - 10.1271/bbb.110745

DO - 10.1271/bbb.110745

M3 - Article

C2 - 22451385

AN - SCOPUS:84859011499

VL - 76

SP - 462

EP - 466

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

SN - 0916-8451

IS - 3

ER -