Effects of macrophage colony-stimulating factor (M-CSF) on the mobilization of peripheral blood stem cells

T. Eto, Y. Takamatsu, M. Harada, N. Harada, K. Akashi, T. Teshima, S. Inaba, T. Okamura, Y. Niho

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9 Citations (Scopus)

Abstract

We studied the effects of human urinary macrophage colony-stimulating factor (huM-CSF) on the mobilization of peripheral blood stem cells (PBSC) following cytotoxic chemotherapy in 6 patients with acute leukemia. After complete remission (CR) was achieved, two courses of consolidation chemotherapy consisting of an intermediate dose of cytosine arabinoside were administered to the patients. During a recovery phase after each course of consolidation chemotherapy, two successive cycles of leukapheresis were performed every other day. M-CSF was administered intravenously at a dose of 8 x 106 U/day during a recovery phase after the second course of consolidation chemotherapy (cytotoxic plus M-CSF mobilization). There was no significant difference in white blood cell (WBC) or platelet recovery between the first and second cycles, regardless of the administration of M-CSF. Furthermore, between cytotoxic and cytotoxic/M-CSF mobilization, significant differences were not observed in the harvest of mononuclear cells (average 1.43 x 108/kg vs 1.62 x 108/kg), granulocyte/macrophage progenitor cells (CFU-GM) (1.82 x 104/kg vs 3.07 x 104/kg) or erythroid progenitor cells (BFU-E) (2.86 x 104/kg vs 2.66 x 104/kg). Thus M-CSF is not effective for expanding a pool of circulating hematopoietic stem cells when administered at a conventional dose during hematologic recovery following chemotherapy.

Original languageEnglish
Pages (from-to)125-129
Number of pages5
JournalBone Marrow Transplantation
Volume13
Issue number2
Publication statusPublished - 1994

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

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