Effects of mood stabilizers on the disruption of prepulse inhibition induced by apomorphine or dizocilpine in mice

Kenta Umeda, Katsuya Suemaru, Nobuko Todo, Nobuaki Egashira, Kenichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara, Hiroaki Araki

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

The prepulse inhibition of the startle response provides an operational measure of sensorimotor gating in which a weak stimulus presented prior to a startling stimulus reduces the startle response. Prepulse inhibition deficits were observed in patients with several neuropsychiatric disorders, including schizophrenia and acute manic bipolar patients. Valproic acid, carbamazepine and lithium carbonate are frequently used as mood stabilizers in patients with bipolar affective disorder and schizophrenia. However, little is known about the mechanisms of action of mood stabilizers on prepulse inhibition deficits. In this study, we investigated the effects of mood stabilizers on the disruption of prepulse inhibition of the acoustic startle response induced by either apomorphine or dizocilpine in mice. Valproate (30-300 mg/kg, i.p.), carbamazepine (3-30 mg/kg, i.p.) and lithium carbonate (10-100 mg/kg, p.o.) had any effect on prepulse inhibition by itself. Valproate, carbamazepine and lithium carbonate reversed the disruption of prepulse inhibition induced by apomorphine (1 mg/kg, s.c.). Although valproate and carbamazepine had no effect on the disruption of prepulse inhibition induced by dizocilpine (0.3 mg/kg, s.c.), lithium carbonate exacerbated the dizocilpine-induced disruption. These results suggest that valproate, carbamazepine and lithium carbonate reverse the disruption of prepulse inhibition through the dopaminergic system.

Original languageEnglish
Pages (from-to)157-162
Number of pages6
JournalEuropean Journal of Pharmacology
Volume553
Issue number1-3
DOIs
Publication statusPublished - Dec 28 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology

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