Abstract
The setting reaction and mechanical strength in terms of diametral tensile strength (DTS) of hydroxyapatite (HAP) putty made of tetracalcium phosphate, dicalcium phosphate anhydrous, and neutral sodium hydrogen phosphate (Na1.8H1.2PO4) solution containing 8 wt % sodium alginate were evaluated as a function of the Na1.8H1.2PO4 concentration. In one condition, HAP putty was placed in an incubator kept at 37°C and 100% relative humidity. In the other condition, immediately after mixing HAP putty was immersed in serum kept at 37°C. Longer setting times and lower DTS values were observed when HAP putty was immersed in serum regardless of the Na1.8H1.2PO4 concentration. The setting times of the HAP putty in both conditions became shorter with an increase in the Na1.8H1.2PO4 concentration, reaching approximately 7-13 min when the Na1.8H1.2PO4 concentration was 0.6 mol/L or higher. The DTS value of HAP putty was relatively constant (10 MPa) regardless of the Na1.8H1.2PO4 concentration (0.2-1.0 mol/L) when HAP putty was kept in an incubator. In contrast, when HAP putty was immersed in serum, the DTS value was dependent on the Na1.8H1.2PO4 concentration. It increased with the Na1.8H1.2PO4 concentration and reached approximately 5 MPa when the Na1.8H1.2PO4 concentration was 0.6 mol/L, after which it showed a relatively constant DTS value. We therefore would recommend a HAP putty that uses 0.6 mol/L Na1.8H1.2PO4 since at that concentration the putty's setting time (approximately 10 min) is proper for clinical use and it shows good DTS value (approximately 5 MPa) even when it is immersed in serum immediately after mixing.
| Original language | English |
|---|---|
| Pages (from-to) | 322-329 |
| Number of pages | 8 |
| Journal | Journal of Biomedical Materials Research |
| Volume | 44 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 5 1999 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Biomaterials
- Biomedical Engineering
Cite this
Effects of neutral sodium hydrogen phosphate on setting reaction and mechanical strength of hydroxyapatite putty. / Ishikawa, Kunio; Miyamoto, Youji; Takechi, Masaaki; Ueyama, Yoshiya; Suzuki, Kazuomi; Nagayama, Masaru; Matsumura, Tomohiro.
In: Journal of Biomedical Materials Research, Vol. 44, No. 3, 05.03.1999, p. 322-329.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of neutral sodium hydrogen phosphate on setting reaction and mechanical strength of hydroxyapatite putty
AU - Ishikawa, Kunio
AU - Miyamoto, Youji
AU - Takechi, Masaaki
AU - Ueyama, Yoshiya
AU - Suzuki, Kazuomi
AU - Nagayama, Masaru
AU - Matsumura, Tomohiro
PY - 1999/3/5
Y1 - 1999/3/5
N2 - The setting reaction and mechanical strength in terms of diametral tensile strength (DTS) of hydroxyapatite (HAP) putty made of tetracalcium phosphate, dicalcium phosphate anhydrous, and neutral sodium hydrogen phosphate (Na1.8H1.2PO4) solution containing 8 wt % sodium alginate were evaluated as a function of the Na1.8H1.2PO4 concentration. In one condition, HAP putty was placed in an incubator kept at 37°C and 100% relative humidity. In the other condition, immediately after mixing HAP putty was immersed in serum kept at 37°C. Longer setting times and lower DTS values were observed when HAP putty was immersed in serum regardless of the Na1.8H1.2PO4 concentration. The setting times of the HAP putty in both conditions became shorter with an increase in the Na1.8H1.2PO4 concentration, reaching approximately 7-13 min when the Na1.8H1.2PO4 concentration was 0.6 mol/L or higher. The DTS value of HAP putty was relatively constant (10 MPa) regardless of the Na1.8H1.2PO4 concentration (0.2-1.0 mol/L) when HAP putty was kept in an incubator. In contrast, when HAP putty was immersed in serum, the DTS value was dependent on the Na1.8H1.2PO4 concentration. It increased with the Na1.8H1.2PO4 concentration and reached approximately 5 MPa when the Na1.8H1.2PO4 concentration was 0.6 mol/L, after which it showed a relatively constant DTS value. We therefore would recommend a HAP putty that uses 0.6 mol/L Na1.8H1.2PO4 since at that concentration the putty's setting time (approximately 10 min) is proper for clinical use and it shows good DTS value (approximately 5 MPa) even when it is immersed in serum immediately after mixing.
AB - The setting reaction and mechanical strength in terms of diametral tensile strength (DTS) of hydroxyapatite (HAP) putty made of tetracalcium phosphate, dicalcium phosphate anhydrous, and neutral sodium hydrogen phosphate (Na1.8H1.2PO4) solution containing 8 wt % sodium alginate were evaluated as a function of the Na1.8H1.2PO4 concentration. In one condition, HAP putty was placed in an incubator kept at 37°C and 100% relative humidity. In the other condition, immediately after mixing HAP putty was immersed in serum kept at 37°C. Longer setting times and lower DTS values were observed when HAP putty was immersed in serum regardless of the Na1.8H1.2PO4 concentration. The setting times of the HAP putty in both conditions became shorter with an increase in the Na1.8H1.2PO4 concentration, reaching approximately 7-13 min when the Na1.8H1.2PO4 concentration was 0.6 mol/L or higher. The DTS value of HAP putty was relatively constant (10 MPa) regardless of the Na1.8H1.2PO4 concentration (0.2-1.0 mol/L) when HAP putty was kept in an incubator. In contrast, when HAP putty was immersed in serum, the DTS value was dependent on the Na1.8H1.2PO4 concentration. It increased with the Na1.8H1.2PO4 concentration and reached approximately 5 MPa when the Na1.8H1.2PO4 concentration was 0.6 mol/L, after which it showed a relatively constant DTS value. We therefore would recommend a HAP putty that uses 0.6 mol/L Na1.8H1.2PO4 since at that concentration the putty's setting time (approximately 10 min) is proper for clinical use and it shows good DTS value (approximately 5 MPa) even when it is immersed in serum immediately after mixing.
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UR - http://www.scopus.com/inward/citedby.url?scp=0033525412&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1097-4636(19990305)44:3<322::AID-JBM11>3.0.CO;2-S
DO - 10.1002/(SICI)1097-4636(19990305)44:3<322::AID-JBM11>3.0.CO;2-S
M3 - Article
C2 - 10397935
AN - SCOPUS:0033525412
VL - 44
SP - 322
EP - 329
JO - Journal of Biomedical Materials Research
JF - Journal of Biomedical Materials Research
SN - 1552-4973
IS - 3
ER -