Effects of oral contraceptive steroids (norethisterone/mestranol) on the activities of hepatic drug-metabolizing enzymes in iron-deficient anemic rats

K. Mizokami; K. Suzuki; K. Inoue; M. Sunouchi; S. Hirakawa; S. Goto; A. Takanaka; Y. Kanke

doi:10.1007/BF02012571

Effects of oral contraceptive steroids (norethisterone/mestranol) on the activities of hepatic drug-metabolizing enzymes in iron-deficient anemic rats

K. Mizokami, K. Suzuki, K. Inoue, M. Sunouchi, S. Hirakawa, S. Goto, A. Takanaka, Y. Kanke

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Either oral contraceptive steroid (norethisterone/mestranol; N/M) treatment or iron-deficiency (Fe(-)) anemia alone caused an increase in NADPH cytochrome c reductase and in three hepatic microsomal mixed-function oxidase activities in female rats. When N/M treatment and the Fe(-) diet are combined, no further change in hepatic enzyme activity is seen compared with that with either treatment alone.

Original language	English
Pages (from-to)	734-736
Number of pages	3
Journal	Experientia
Volume	41
Issue number	6
DOIs	https://doi.org/10.1007/BF02012571
Publication status	Published - Jun 1985
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/BF02012571

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author = "K. Mizokami and K. Suzuki and K. Inoue and M. Sunouchi and S. Hirakawa and S. Goto and A. Takanaka and Y. Kanke",

year = "1985",

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AU - Suzuki, K.

AU - Inoue, K.

AU - Sunouchi, M.

AU - Hirakawa, S.

AU - Goto, S.

AU - Takanaka, A.

AU - Kanke, Y.

PY - 1985/6

Y1 - 1985/6

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AB - Either oral contraceptive steroid (norethisterone/mestranol; N/M) treatment or iron-deficiency (Fe(-)) anemia alone caused an increase in NADPH cytochrome c reductase and in three hepatic microsomal mixed-function oxidase activities in female rats. When N/M treatment and the Fe(-) diet are combined, no further change in hepatic enzyme activity is seen compared with that with either treatment alone.

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ER -

Effects of oral contraceptive steroids (norethisterone/mestranol) on the activities of hepatic drug-metabolizing enzymes in iron-deficient anemic rats

Abstract

All Science Journal Classification (ASJC) codes

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