Effects of oral contraceptive steroids (norethisterone/mestranol) on the activities of hepatic drug-metabolizing enzymes in iron-deficient anemic rats

K. Mizokami, K. Suzuki, K. Inoue, M. Sunouchi, S. Hirakawa, S. Goto, A. Takanaka, Y. Kanke

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Abstract

Either oral contraceptive steroid (norethisterone/mestranol; N/M) treatment or iron-deficiency (Fe(-)) anemia alone caused an increase in NADPH cytochrome c reductase and in three hepatic microsomal mixed-function oxidase activities in female rats. When N/M treatment and the Fe(-) diet are combined, no further change in hepatic enzyme activity is seen compared with that with either treatment alone.

Original languageEnglish
Pages (from-to)734-736
Number of pages3
JournalExperientia
Volume41
Issue number6
DOIs
Publication statusPublished - Jun 1 1985
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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