Effects of organic molecules in the Kokubo's simulated body fluid on apatite formation on bioactive glass and titanium substrates

K. Tsuru, Y. Higashi, S. Hayakawa, A. Osaka

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Abstract

Kokubo's simulated body fluid (SBF) has been extensively used for screening to distinguish bioactive materials. The present study examined the effects of organic acids and albumin in the SBF on apatite formation on glass and titanium substrates. Titanium substrates were subject to a H2O2 treatment and subsequent heating to prepare bioactive titania layers. Apatite formation was then examined after soaking the substrates in both SBF and modified SBF containing organic components such as succinic acid, tartaric acid, citric acid and albumin. Calcium-chelate formation due to the organics reduced free calcium ion concentration. The induction time of apatite nucleation on the titania surface was delayed in SBF containing the organic acids. The reduction in the free calcium ion concentration suppressed the apatite nucleation.

Original languageEnglish
Pages103-110
Number of pages8
Publication statusPublished - Dec 1 2003
EventBioceramics: Materials and Applications IV, Proceedings - Nashville, TN, United States
Duration: Apr 27 2003Apr 30 2003

Other

OtherBioceramics: Materials and Applications IV, Proceedings
CountryUnited States
CityNashville, TN
Period4/27/034/30/03

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All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Materials Chemistry

Cite this

Tsuru, K., Higashi, Y., Hayakawa, S., & Osaka, A. (2003). Effects of organic molecules in the Kokubo's simulated body fluid on apatite formation on bioactive glass and titanium substrates. 103-110. Paper presented at Bioceramics: Materials and Applications IV, Proceedings, Nashville, TN, United States.