Effects of oxygen aeration on production of monoclonal antibody in immobilized hybridoma-cell bioreactor

Masamichi Kamihira, Hitoshi Yoshida, Shinji Iijima, Takeshi Kobayashi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Continuous production of monoclonal antibody by hybridoma cells immobilized with alginate and urethane polymer was done using a fluidized bed bioreactor with direct bubbling. Increasing the dilution rate did not affect the antibody production rate under aeration with air. By changing the aeration gas to oxygen instead of air, the antibody production rate was increased 2-fold. The monoclonal antibody could be produced continuously for more than 40 d.

Original languageEnglish
Pages (from-to)311-312
Number of pages2
JournalJournal of Fermentation and Bioengineering
Volume69
Issue number5
DOIs
Publication statusPublished - 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology

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