Effects of particulate debris on the release of MMP-2 and MMP-9 from human macrophages in vitro

Y. Nakashima, W. J. Maloney, S. B. Goodman, D. H. Sun, D. J. Schurman, R. L. Smith

Research output: Contribution to conferencePaper

Abstract

The effects of metallic debris and bone cement (PMMA) particles on the release of neural metalloproteinases from human macrophages in vitro are studied. Results demonstrated that both titanium alloy debris and PMMA particles induced MMP-9 in isolated macrophages. It is noted that MMP-9 is the predominant metalloproteinase from macrophages and MMP-2 is expressed only at higher particle concentrations. The results confirm the hypothesis that macrophages respond to particles by releasing matrix metalloproteinases.

Original languageEnglish
Number of pages1
Publication statusPublished - 1996
Externally publishedYes
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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