Effects of particulate debris on the release of MMP-2 and MMP-9 from human macrophages in vitro

Yasuharu Nakashima, W. J. Maloney, S. B. Goodman, D. H. Sun, D. J. Schurman, R. L. Smith

Research output: Contribution to conferencePaper

Abstract

The effects of metallic debris and bone cement (PMMA) particles on the release of neural metalloproteinases from human macrophages in vitro are studied. Results demonstrated that both titanium alloy debris and PMMA particles induced MMP-9 in isolated macrophages. It is noted that MMP-9 is the predominant metalloproteinase from macrophages and MMP-2 is expressed only at higher particle concentrations. The results confirm the hypothesis that macrophages respond to particles by releasing matrix metalloproteinases.

Original languageEnglish
Number of pages1
Publication statusPublished - Dec 1 1996
Externally publishedYes
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

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Macrophages
Matrix Metalloproteinases
Debris
Metalloproteases
Polymethyl Methacrylate
Bone cement
Bone Cements
Titanium alloys

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Nakashima, Y., Maloney, W. J., Goodman, S. B., Sun, D. H., Schurman, D. J., & Smith, R. L. (1996). Effects of particulate debris on the release of MMP-2 and MMP-9 from human macrophages in vitro. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .

Effects of particulate debris on the release of MMP-2 and MMP-9 from human macrophages in vitro. / Nakashima, Yasuharu; Maloney, W. J.; Goodman, S. B.; Sun, D. H.; Schurman, D. J.; Smith, R. L.

1996. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .

Research output: Contribution to conferencePaper

Nakashima, Y, Maloney, WJ, Goodman, SB, Sun, DH, Schurman, DJ & Smith, RL 1996, 'Effects of particulate debris on the release of MMP-2 and MMP-9 from human macrophages in vitro', Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, 5/29/96 - 6/2/96.
Nakashima Y, Maloney WJ, Goodman SB, Sun DH, Schurman DJ, Smith RL. Effects of particulate debris on the release of MMP-2 and MMP-9 from human macrophages in vitro. 1996. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .
Nakashima, Yasuharu ; Maloney, W. J. ; Goodman, S. B. ; Sun, D. H. ; Schurman, D. J. ; Smith, R. L. / Effects of particulate debris on the release of MMP-2 and MMP-9 from human macrophages in vitro. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .1 p.
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AU - Schurman, D. J.

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