Effects of penicillin on clinical tests with special reference to serum albumin measured by a modified BCP method

Yuzo Kayamori, Miyuki Ono, Dongchon Kang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Penicillin derivatives are widely used for treatment of bacterial infection. A high-dose penicillin is recommended as a first choice particularly for infective endocarditis in the guideline from the American Heart Association. We found two patients with infective endocarditis who had serum albumin shifting to a cathode side on the electrophoresis. The both patients had been treated with a high-dose penicillin G. The serum albumin concentrations of the patients were 1.7 g/dL and 1.8 g/dL when measured by a modified bromocresol purple (BCP) method while they were 3.4 and 3.3, respectively, by a bromocresol green (BCG) method. To confirm these low values obtained by the modified BCP method are due to the high-dose penicillin G therapy, we added penicillin G in normal sera and measured albumin concentration by the BCP and BCG methods. Exogenously added penicillin G inhibited the BCP reaction in dose-dependent and incubation time-dependent manners but not the BCG reaction. Here, we generally describe effects of penicillin derivatives on serum albumin measurement and other clinical tests.

Original languageEnglish
Title of host publicationPenicillin
Subtitle of host publicationBiosynthesis, Applications and Adverse Effects
PublisherNova Science Publishers, Inc.
Pages113-126
Number of pages14
ISBN (Print)9781621002338
Publication statusPublished - Jan 1 2012

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Kayamori, Y., Ono, M., & Kang, D. (2012). Effects of penicillin on clinical tests with special reference to serum albumin measured by a modified BCP method. In Penicillin: Biosynthesis, Applications and Adverse Effects (pp. 113-126). Nova Science Publishers, Inc..