Effects of percutaneous stimulation of both sympathetic and parasympathetic cardiac autonomic nerves on cardiac function in dogs

Mariko Kobayashi, Seiichiro Sakurai, Tohru Takaseya, Akira Shiose, Hyun Il Kim, Masako Fujiki, Jamshid H. Karimov, Raymond Dessoffy, Alex Massiello, Allen G. Borowski, David R. Van Wagoner, Eugene Jung, Kiyotaka Fukamachi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

OBJECTIVE: Augmentation of left ventricular (LV) contractility and heart rate (HR) by sympathetic nerve stimulation and amelioration of heart failure by vagal nerve stimulation has been reported. However, the effects of concomitant electrical stimulation of both sympathetic and parasympathetic cardiac nerves in tissues such as those of the cardiac plexus remain unclear. This study sought to assess acute changes in cardiac function and hemodynamics in response to endovascular cardiac plexus stimulation (CPS). METHODS: Twelve dogs received endovascular CPS via a bipolar catheter within the right pulmonary artery. Stimulation frequency (20 Hz) and pulse width (4 milliseconds) were fixed; voltage varied (range, 15-60 V). RESULTS: Results fell into three categories: 1, no response (n = 4); 2, an increase in systemic arterial pressure that was dependent on electrode placement (n = 4); and 3, a very reproducible and stable increase in aortic pressure (n = 4). In the third group, mean systolic aortic pressures, maximum value of the first derivative of LV pressure, and LV stroke work increased with stimulation (P < 0.02 for all parameters) as did cardiac output, end-systolic elastance, and preload recruitable stroke work (P = 0.03). Systemic and pulmonary vascular resistance, central venous pressure, pulmonary arterial pressure, and HR remained unchanged (P > 0.05). CONCLUSIONS: In contrast to conventional inotropic agents, endovascular CPS induced significant and selective increases in LV contractility without increasing HR. Efforts to optimize electrode placement and fixation will improve the reproducibility of endovascular CPS treatment.

Original languageEnglish
Pages (from-to)282-289
Number of pages8
JournalInnovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
Volume7
Issue number4
DOIs
Publication statusPublished - Jul 1 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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    Kobayashi, M., Sakurai, S., Takaseya, T., Shiose, A., Kim, H. I., Fujiki, M., Karimov, J. H., Dessoffy, R., Massiello, A., Borowski, A. G., Van Wagoner, D. R., Jung, E., & Fukamachi, K. (2012). Effects of percutaneous stimulation of both sympathetic and parasympathetic cardiac autonomic nerves on cardiac function in dogs. Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery, 7(4), 282-289. https://doi.org/10.1097/IMI.0b013e31826f14ff