Effects of percutaneous stimulation of both sympathetic and parasympathetic cardiac autonomic nerves on cardiac function in dogs

Mariko Kobayashi, Seiichiro Sakurai, Tohru Takaseya, Akira Shiose, Hyun Il Kim, Masako Fujiki, Jamshid H. Karimov, Raymond Dessoffy, Alex Massiello, Allen G. Borowski, David R. Van Wagoner, Eugene Jung, Kiyotaka Fukamachi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

OBJECTIVE: Augmentation of left ventricular (LV) contractility and heart rate (HR) by sympathetic nerve stimulation and amelioration of heart failure by vagal nerve stimulation has been reported. However, the effects of concomitant electrical stimulation of both sympathetic and parasympathetic cardiac nerves in tissues such as those of the cardiac plexus remain unclear. This study sought to assess acute changes in cardiac function and hemodynamics in response to endovascular cardiac plexus stimulation (CPS). METHODS: Twelve dogs received endovascular CPS via a bipolar catheter within the right pulmonary artery. Stimulation frequency (20 Hz) and pulse width (4 milliseconds) were fixed; voltage varied (range, 15-60 V). RESULTS: Results fell into three categories: 1, no response (n = 4); 2, an increase in systemic arterial pressure that was dependent on electrode placement (n = 4); and 3, a very reproducible and stable increase in aortic pressure (n = 4). In the third group, mean systolic aortic pressures, maximum value of the first derivative of LV pressure, and LV stroke work increased with stimulation (P < 0.02 for all parameters) as did cardiac output, end-systolic elastance, and preload recruitable stroke work (P = 0.03). Systemic and pulmonary vascular resistance, central venous pressure, pulmonary arterial pressure, and HR remained unchanged (P > 0.05). CONCLUSIONS: In contrast to conventional inotropic agents, endovascular CPS induced significant and selective increases in LV contractility without increasing HR. Efforts to optimize electrode placement and fixation will improve the reproducibility of endovascular CPS treatment.

Original languageEnglish
Pages (from-to)282-289
Number of pages8
JournalInnovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
Volume7
Issue number4
DOIs
Publication statusPublished - Jul 1 2012

Fingerprint

Autonomic Pathways
Arterial Pressure
Dogs
Electrodes
Heart Rate
Vagus Nerve Stimulation
Nerve Tissue
Ventricular Pressure
Pulmonary Artery
Electric Stimulation
Pulse
Catheters
Heart Failure
Hemodynamics
Stroke
Blood Pressure
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Effects of percutaneous stimulation of both sympathetic and parasympathetic cardiac autonomic nerves on cardiac function in dogs. / Kobayashi, Mariko; Sakurai, Seiichiro; Takaseya, Tohru; Shiose, Akira; Kim, Hyun Il; Fujiki, Masako; Karimov, Jamshid H.; Dessoffy, Raymond; Massiello, Alex; Borowski, Allen G.; Van Wagoner, David R.; Jung, Eugene; Fukamachi, Kiyotaka.

In: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery, Vol. 7, No. 4, 01.07.2012, p. 282-289.

Research output: Contribution to journalArticle

Kobayashi, M, Sakurai, S, Takaseya, T, Shiose, A, Kim, HI, Fujiki, M, Karimov, JH, Dessoffy, R, Massiello, A, Borowski, AG, Van Wagoner, DR, Jung, E & Fukamachi, K 2012, 'Effects of percutaneous stimulation of both sympathetic and parasympathetic cardiac autonomic nerves on cardiac function in dogs', Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery, vol. 7, no. 4, pp. 282-289. https://doi.org/10.1097/IMI.0b013e31826f14ff
Kobayashi, Mariko ; Sakurai, Seiichiro ; Takaseya, Tohru ; Shiose, Akira ; Kim, Hyun Il ; Fujiki, Masako ; Karimov, Jamshid H. ; Dessoffy, Raymond ; Massiello, Alex ; Borowski, Allen G. ; Van Wagoner, David R. ; Jung, Eugene ; Fukamachi, Kiyotaka. / Effects of percutaneous stimulation of both sympathetic and parasympathetic cardiac autonomic nerves on cardiac function in dogs. In: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery. 2012 ; Vol. 7, No. 4. pp. 282-289.
@article{ca014562a37a4767ae4e05272891cacf,
title = "Effects of percutaneous stimulation of both sympathetic and parasympathetic cardiac autonomic nerves on cardiac function in dogs",
abstract = "OBJECTIVE: Augmentation of left ventricular (LV) contractility and heart rate (HR) by sympathetic nerve stimulation and amelioration of heart failure by vagal nerve stimulation has been reported. However, the effects of concomitant electrical stimulation of both sympathetic and parasympathetic cardiac nerves in tissues such as those of the cardiac plexus remain unclear. This study sought to assess acute changes in cardiac function and hemodynamics in response to endovascular cardiac plexus stimulation (CPS). METHODS: Twelve dogs received endovascular CPS via a bipolar catheter within the right pulmonary artery. Stimulation frequency (20 Hz) and pulse width (4 milliseconds) were fixed; voltage varied (range, 15-60 V). RESULTS: Results fell into three categories: 1, no response (n = 4); 2, an increase in systemic arterial pressure that was dependent on electrode placement (n = 4); and 3, a very reproducible and stable increase in aortic pressure (n = 4). In the third group, mean systolic aortic pressures, maximum value of the first derivative of LV pressure, and LV stroke work increased with stimulation (P < 0.02 for all parameters) as did cardiac output, end-systolic elastance, and preload recruitable stroke work (P = 0.03). Systemic and pulmonary vascular resistance, central venous pressure, pulmonary arterial pressure, and HR remained unchanged (P > 0.05). CONCLUSIONS: In contrast to conventional inotropic agents, endovascular CPS induced significant and selective increases in LV contractility without increasing HR. Efforts to optimize electrode placement and fixation will improve the reproducibility of endovascular CPS treatment.",
author = "Mariko Kobayashi and Seiichiro Sakurai and Tohru Takaseya and Akira Shiose and Kim, {Hyun Il} and Masako Fujiki and Karimov, {Jamshid H.} and Raymond Dessoffy and Alex Massiello and Borowski, {Allen G.} and {Van Wagoner}, {David R.} and Eugene Jung and Kiyotaka Fukamachi",
year = "2012",
month = "7",
day = "1",
doi = "10.1097/IMI.0b013e31826f14ff",
language = "English",
volume = "7",
pages = "282--289",
journal = "Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery",
issn = "1556-9845",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Effects of percutaneous stimulation of both sympathetic and parasympathetic cardiac autonomic nerves on cardiac function in dogs

AU - Kobayashi, Mariko

AU - Sakurai, Seiichiro

AU - Takaseya, Tohru

AU - Shiose, Akira

AU - Kim, Hyun Il

AU - Fujiki, Masako

AU - Karimov, Jamshid H.

AU - Dessoffy, Raymond

AU - Massiello, Alex

AU - Borowski, Allen G.

AU - Van Wagoner, David R.

AU - Jung, Eugene

AU - Fukamachi, Kiyotaka

PY - 2012/7/1

Y1 - 2012/7/1

N2 - OBJECTIVE: Augmentation of left ventricular (LV) contractility and heart rate (HR) by sympathetic nerve stimulation and amelioration of heart failure by vagal nerve stimulation has been reported. However, the effects of concomitant electrical stimulation of both sympathetic and parasympathetic cardiac nerves in tissues such as those of the cardiac plexus remain unclear. This study sought to assess acute changes in cardiac function and hemodynamics in response to endovascular cardiac plexus stimulation (CPS). METHODS: Twelve dogs received endovascular CPS via a bipolar catheter within the right pulmonary artery. Stimulation frequency (20 Hz) and pulse width (4 milliseconds) were fixed; voltage varied (range, 15-60 V). RESULTS: Results fell into three categories: 1, no response (n = 4); 2, an increase in systemic arterial pressure that was dependent on electrode placement (n = 4); and 3, a very reproducible and stable increase in aortic pressure (n = 4). In the third group, mean systolic aortic pressures, maximum value of the first derivative of LV pressure, and LV stroke work increased with stimulation (P < 0.02 for all parameters) as did cardiac output, end-systolic elastance, and preload recruitable stroke work (P = 0.03). Systemic and pulmonary vascular resistance, central venous pressure, pulmonary arterial pressure, and HR remained unchanged (P > 0.05). CONCLUSIONS: In contrast to conventional inotropic agents, endovascular CPS induced significant and selective increases in LV contractility without increasing HR. Efforts to optimize electrode placement and fixation will improve the reproducibility of endovascular CPS treatment.

AB - OBJECTIVE: Augmentation of left ventricular (LV) contractility and heart rate (HR) by sympathetic nerve stimulation and amelioration of heart failure by vagal nerve stimulation has been reported. However, the effects of concomitant electrical stimulation of both sympathetic and parasympathetic cardiac nerves in tissues such as those of the cardiac plexus remain unclear. This study sought to assess acute changes in cardiac function and hemodynamics in response to endovascular cardiac plexus stimulation (CPS). METHODS: Twelve dogs received endovascular CPS via a bipolar catheter within the right pulmonary artery. Stimulation frequency (20 Hz) and pulse width (4 milliseconds) were fixed; voltage varied (range, 15-60 V). RESULTS: Results fell into three categories: 1, no response (n = 4); 2, an increase in systemic arterial pressure that was dependent on electrode placement (n = 4); and 3, a very reproducible and stable increase in aortic pressure (n = 4). In the third group, mean systolic aortic pressures, maximum value of the first derivative of LV pressure, and LV stroke work increased with stimulation (P < 0.02 for all parameters) as did cardiac output, end-systolic elastance, and preload recruitable stroke work (P = 0.03). Systemic and pulmonary vascular resistance, central venous pressure, pulmonary arterial pressure, and HR remained unchanged (P > 0.05). CONCLUSIONS: In contrast to conventional inotropic agents, endovascular CPS induced significant and selective increases in LV contractility without increasing HR. Efforts to optimize electrode placement and fixation will improve the reproducibility of endovascular CPS treatment.

UR - http://www.scopus.com/inward/record.url?scp=84869796335&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869796335&partnerID=8YFLogxK

U2 - 10.1097/IMI.0b013e31826f14ff

DO - 10.1097/IMI.0b013e31826f14ff

M3 - Article

C2 - 23123996

AN - SCOPUS:84869796335

VL - 7

SP - 282

EP - 289

JO - Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery

JF - Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery

SN - 1556-9845

IS - 4

ER -