Effects of phenylephrine and prostaglandin E 1 on ventriculo-arterial matching during halothane anaesthesia

Sumio Hoka, T. Kawasaki, H. Okamoto, T. Okuyama, S. Takahashi

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2 Citations (Scopus)

Abstract

We have investigated the effects of phenylephrine alone and combined with prostaglandin E 1 (PGE 1 ) on ventriculo-arterial matching during halothane anaesthesia in dogs. The ratio of left ventricular end-systolic elastance (Ees) to effective arterial elastance (Ea) was used as an index of ventriculo-arterial matching. In group 1 (n = 7), measurements were performed at control, 1.5% halothane, halothane + phenylephrine 1-10 μg kg -1 min -1 , and halothane + phenylephrine + PGE 1 0.2-1.0 or 1.0-2.0 μg kg -1 min -1 . In group 2 (n = 5), dobutamine 2 and 5 μg kg -1 min -1 was infused during halothane anaesthesia. Halothane 1.5% decreased mean arterial pressure (MAP), cardiac output and Ees. Phenylephrine restored MAP, but further decreased cardiac output. The decrease in Ees produced by halothane was reversed by phenylephrine. PGE 1 increased cardiac output and reversed the increases in Ea and Ea/Ees during phenylephrine infusion. Dobutamine also reversed halothane-induced decreases in MAP, cardiac output and Ees, and improved Ea/Ees. Our results indicate that combined use of PGE 1 with phenylephrine can eliminate the vasoconstrictive property of phenylephrine, resulting in an improvement in ventriculo-arterial matching.

Original languageEnglish
Pages (from-to)438-442
Number of pages5
JournalBritish Journal of Anaesthesia
Volume74
Issue number4
DOIs
Publication statusPublished - Jan 1 1995

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Phenylephrine
Halothane
Prostaglandins E
Anesthesia
Cardiac Output
Arterial Pressure
Dobutamine
Dogs

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

Effects of phenylephrine and prostaglandin E 1 on ventriculo-arterial matching during halothane anaesthesia . / Hoka, Sumio; Kawasaki, T.; Okamoto, H.; Okuyama, T.; Takahashi, S.

In: British Journal of Anaesthesia, Vol. 74, No. 4, 01.01.1995, p. 438-442.

Research output: Contribution to journalArticle

Hoka, Sumio ; Kawasaki, T. ; Okamoto, H. ; Okuyama, T. ; Takahashi, S. / Effects of phenylephrine and prostaglandin E 1 on ventriculo-arterial matching during halothane anaesthesia In: British Journal of Anaesthesia. 1995 ; Vol. 74, No. 4. pp. 438-442.
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