Effects of phenylephrine and prostaglandin E1 on ventriculo-arterial matching during halothane anaesthesia

S. Hoka, T. Kawasaki, H. Okamoto, T. Okuyama, S. Takahashi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We have investigated the effects of phenylephrine alone and combined with prostaglandin E1 (PGE1) on ventriculo-arterial matching during halothane anaesthesia in dogs. The ratio of left ventricular end-systolic elastance (Ees) to effective arterial elastance (Ea) was used as an index of ventriculo-arterial matching. In group 1 (n = 7), measurements were performed at control, 1.5% halothane, halothane + phenylephrine 1-10 μg kg-1 min-1, and halothane + phenylephrine + PGE1 0.2-1.0 or 1.0-2.0 μg kg-1 min-1. In group 2 (n = 5), dobutamine 2 and 5 μg kg-1 min-1 was infused during halothane anaesthesia. Halothane 1.5% decreased mean arterial pressure (MAP), cardiac output and Ees. Phenylephrine restored MAP, but further decreased cardiac output. The decrease in Ees produced by halothane was reversed by phenylephrine. PGE1 increased cardiac output and reversed the increases in Ea and Ea/Ees during phenylephrine infusion. Dobutamine also reversed halothane-induced decreases in MAP, cardiac output and Ees, and improved Ea/Ees. Our results indicate that combined use of PGE1 with phenylephrine can eliminate the vasoconstrictive property of phenylephrine, resulting in an improvement in ventriculo-arterial matching.

Original languageEnglish
Pages (from-to)438-442
Number of pages5
JournalBritish Journal of Anaesthesia
Volume74
Issue number4
DOIs
Publication statusPublished - Jan 1 1995

Fingerprint

Alprostadil
Phenylephrine
Halothane
Anesthesia
Cardiac Output
Arterial Pressure
Dobutamine
Dogs

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

Effects of phenylephrine and prostaglandin E1 on ventriculo-arterial matching during halothane anaesthesia. / Hoka, S.; Kawasaki, T.; Okamoto, H.; Okuyama, T.; Takahashi, S.

In: British Journal of Anaesthesia, Vol. 74, No. 4, 01.01.1995, p. 438-442.

Research output: Contribution to journalArticle

Hoka, S. ; Kawasaki, T. ; Okamoto, H. ; Okuyama, T. ; Takahashi, S. / Effects of phenylephrine and prostaglandin E1 on ventriculo-arterial matching during halothane anaesthesia. In: British Journal of Anaesthesia. 1995 ; Vol. 74, No. 4. pp. 438-442.
@article{f7d30fd5996a4b439f8d940b2b65ee4a,
title = "Effects of phenylephrine and prostaglandin E1 on ventriculo-arterial matching during halothane anaesthesia",
abstract = "We have investigated the effects of phenylephrine alone and combined with prostaglandin E1 (PGE1) on ventriculo-arterial matching during halothane anaesthesia in dogs. The ratio of left ventricular end-systolic elastance (Ees) to effective arterial elastance (Ea) was used as an index of ventriculo-arterial matching. In group 1 (n = 7), measurements were performed at control, 1.5{\%} halothane, halothane + phenylephrine 1-10 μg kg-1 min-1, and halothane + phenylephrine + PGE1 0.2-1.0 or 1.0-2.0 μg kg-1 min-1. In group 2 (n = 5), dobutamine 2 and 5 μg kg-1 min-1 was infused during halothane anaesthesia. Halothane 1.5{\%} decreased mean arterial pressure (MAP), cardiac output and Ees. Phenylephrine restored MAP, but further decreased cardiac output. The decrease in Ees produced by halothane was reversed by phenylephrine. PGE1 increased cardiac output and reversed the increases in Ea and Ea/Ees during phenylephrine infusion. Dobutamine also reversed halothane-induced decreases in MAP, cardiac output and Ees, and improved Ea/Ees. Our results indicate that combined use of PGE1 with phenylephrine can eliminate the vasoconstrictive property of phenylephrine, resulting in an improvement in ventriculo-arterial matching.",
author = "S. Hoka and T. Kawasaki and H. Okamoto and T. Okuyama and S. Takahashi",
year = "1995",
month = "1",
day = "1",
doi = "10.1093/bja/74.4.438",
language = "English",
volume = "74",
pages = "438--442",
journal = "British Journal of Anaesthesia",
issn = "0007-0912",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - Effects of phenylephrine and prostaglandin E1 on ventriculo-arterial matching during halothane anaesthesia

AU - Hoka, S.

AU - Kawasaki, T.

AU - Okamoto, H.

AU - Okuyama, T.

AU - Takahashi, S.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - We have investigated the effects of phenylephrine alone and combined with prostaglandin E1 (PGE1) on ventriculo-arterial matching during halothane anaesthesia in dogs. The ratio of left ventricular end-systolic elastance (Ees) to effective arterial elastance (Ea) was used as an index of ventriculo-arterial matching. In group 1 (n = 7), measurements were performed at control, 1.5% halothane, halothane + phenylephrine 1-10 μg kg-1 min-1, and halothane + phenylephrine + PGE1 0.2-1.0 or 1.0-2.0 μg kg-1 min-1. In group 2 (n = 5), dobutamine 2 and 5 μg kg-1 min-1 was infused during halothane anaesthesia. Halothane 1.5% decreased mean arterial pressure (MAP), cardiac output and Ees. Phenylephrine restored MAP, but further decreased cardiac output. The decrease in Ees produced by halothane was reversed by phenylephrine. PGE1 increased cardiac output and reversed the increases in Ea and Ea/Ees during phenylephrine infusion. Dobutamine also reversed halothane-induced decreases in MAP, cardiac output and Ees, and improved Ea/Ees. Our results indicate that combined use of PGE1 with phenylephrine can eliminate the vasoconstrictive property of phenylephrine, resulting in an improvement in ventriculo-arterial matching.

AB - We have investigated the effects of phenylephrine alone and combined with prostaglandin E1 (PGE1) on ventriculo-arterial matching during halothane anaesthesia in dogs. The ratio of left ventricular end-systolic elastance (Ees) to effective arterial elastance (Ea) was used as an index of ventriculo-arterial matching. In group 1 (n = 7), measurements were performed at control, 1.5% halothane, halothane + phenylephrine 1-10 μg kg-1 min-1, and halothane + phenylephrine + PGE1 0.2-1.0 or 1.0-2.0 μg kg-1 min-1. In group 2 (n = 5), dobutamine 2 and 5 μg kg-1 min-1 was infused during halothane anaesthesia. Halothane 1.5% decreased mean arterial pressure (MAP), cardiac output and Ees. Phenylephrine restored MAP, but further decreased cardiac output. The decrease in Ees produced by halothane was reversed by phenylephrine. PGE1 increased cardiac output and reversed the increases in Ea and Ea/Ees during phenylephrine infusion. Dobutamine also reversed halothane-induced decreases in MAP, cardiac output and Ees, and improved Ea/Ees. Our results indicate that combined use of PGE1 with phenylephrine can eliminate the vasoconstrictive property of phenylephrine, resulting in an improvement in ventriculo-arterial matching.

UR - http://www.scopus.com/inward/record.url?scp=0028936802&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028936802&partnerID=8YFLogxK

U2 - 10.1093/bja/74.4.438

DO - 10.1093/bja/74.4.438

M3 - Article

C2 - 7734265

AN - SCOPUS:0028936802

VL - 74

SP - 438

EP - 442

JO - British Journal of Anaesthesia

JF - British Journal of Anaesthesia

SN - 0007-0912

IS - 4

ER -