Effects of plasmalogens on systemic lipopolysaccharide-induced glial activation and β-amyloid accumulation in adult mice

Toshihiko Katafuchi, Masataka Ifuku, Shiro Mawatari, Mami Noda, Kiyotaka Miake, Masaaki Sugiyama, Takehiko Fujino

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Neuroinflammation essentially involves an activation of glial cells as the cause/effect of neurodegenerative diseases such as Alzheimer's disease (AD). Plasmalogens (Pls) are glycerophospholipids constituting cellular membranes and play significant roles in membrane fluidity and cellular processes like vesicular fusion and signal transduction. Intraperitoneal (i.p.) injection of lipopolysaccharide (LPS, 250 μg/kg) for 7 days resulted in the morphological changes and increase in number of Iba-1+ microglia showing neuroinflammation in the adult mouse hippocampus. The LPS-induced activation of glial cells was significantly attenuated by i.p. pretreatment with Pls dissolved in corn oil. In addition, systemic injection of LPS induced Aβ1-16+ neurons in the hippocampus were also abolished by application of Pls. Finally, contents of Pls in the hippocampus decreased after LPS injection, and the reduction was suppressed by administration of Pls. These findings suggest an antiamyloidogenic effect of Pls, implicating a possible therapeutic application of Pls against AD.

Original languageEnglish
Pages (from-to)85-92
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume1262
Issue number1
DOIs
Publication statusPublished - Jul 2012

Fingerprint

Plasmalogens
Amyloid
Neuroglia
Lipopolysaccharides
Chemical activation
Hippocampus
Alzheimer Disease
Neurodegenerative diseases
Glycerophospholipids
Membranes
Signal transduction
Injections
Membrane Fluidity
Corn Oil
Fluidity
Microglia
Activation
Mouse
Intraperitoneal Injections
Neurodegenerative Diseases

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Effects of plasmalogens on systemic lipopolysaccharide-induced glial activation and β-amyloid accumulation in adult mice. / Katafuchi, Toshihiko; Ifuku, Masataka; Mawatari, Shiro; Noda, Mami; Miake, Kiyotaka; Sugiyama, Masaaki; Fujino, Takehiko.

In: Annals of the New York Academy of Sciences, Vol. 1262, No. 1, 07.2012, p. 85-92.

Research output: Contribution to journalArticle

Katafuchi, Toshihiko ; Ifuku, Masataka ; Mawatari, Shiro ; Noda, Mami ; Miake, Kiyotaka ; Sugiyama, Masaaki ; Fujino, Takehiko. / Effects of plasmalogens on systemic lipopolysaccharide-induced glial activation and β-amyloid accumulation in adult mice. In: Annals of the New York Academy of Sciences. 2012 ; Vol. 1262, No. 1. pp. 85-92.
@article{212539f8ba784d75b503c7d0bc825b8a,
title = "Effects of plasmalogens on systemic lipopolysaccharide-induced glial activation and β-amyloid accumulation in adult mice",
abstract = "Neuroinflammation essentially involves an activation of glial cells as the cause/effect of neurodegenerative diseases such as Alzheimer's disease (AD). Plasmalogens (Pls) are glycerophospholipids constituting cellular membranes and play significant roles in membrane fluidity and cellular processes like vesicular fusion and signal transduction. Intraperitoneal (i.p.) injection of lipopolysaccharide (LPS, 250 μg/kg) for 7 days resulted in the morphological changes and increase in number of Iba-1+ microglia showing neuroinflammation in the adult mouse hippocampus. The LPS-induced activation of glial cells was significantly attenuated by i.p. pretreatment with Pls dissolved in corn oil. In addition, systemic injection of LPS induced Aβ1-16+ neurons in the hippocampus were also abolished by application of Pls. Finally, contents of Pls in the hippocampus decreased after LPS injection, and the reduction was suppressed by administration of Pls. These findings suggest an antiamyloidogenic effect of Pls, implicating a possible therapeutic application of Pls against AD.",
author = "Toshihiko Katafuchi and Masataka Ifuku and Shiro Mawatari and Mami Noda and Kiyotaka Miake and Masaaki Sugiyama and Takehiko Fujino",
year = "2012",
month = "7",
doi = "10.1111/j.1749-6632.2012.06641.x",
language = "English",
volume = "1262",
pages = "85--92",
journal = "Annals of the New York Academy of Sciences",
issn = "0077-8923",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Effects of plasmalogens on systemic lipopolysaccharide-induced glial activation and β-amyloid accumulation in adult mice

AU - Katafuchi, Toshihiko

AU - Ifuku, Masataka

AU - Mawatari, Shiro

AU - Noda, Mami

AU - Miake, Kiyotaka

AU - Sugiyama, Masaaki

AU - Fujino, Takehiko

PY - 2012/7

Y1 - 2012/7

N2 - Neuroinflammation essentially involves an activation of glial cells as the cause/effect of neurodegenerative diseases such as Alzheimer's disease (AD). Plasmalogens (Pls) are glycerophospholipids constituting cellular membranes and play significant roles in membrane fluidity and cellular processes like vesicular fusion and signal transduction. Intraperitoneal (i.p.) injection of lipopolysaccharide (LPS, 250 μg/kg) for 7 days resulted in the morphological changes and increase in number of Iba-1+ microglia showing neuroinflammation in the adult mouse hippocampus. The LPS-induced activation of glial cells was significantly attenuated by i.p. pretreatment with Pls dissolved in corn oil. In addition, systemic injection of LPS induced Aβ1-16+ neurons in the hippocampus were also abolished by application of Pls. Finally, contents of Pls in the hippocampus decreased after LPS injection, and the reduction was suppressed by administration of Pls. These findings suggest an antiamyloidogenic effect of Pls, implicating a possible therapeutic application of Pls against AD.

AB - Neuroinflammation essentially involves an activation of glial cells as the cause/effect of neurodegenerative diseases such as Alzheimer's disease (AD). Plasmalogens (Pls) are glycerophospholipids constituting cellular membranes and play significant roles in membrane fluidity and cellular processes like vesicular fusion and signal transduction. Intraperitoneal (i.p.) injection of lipopolysaccharide (LPS, 250 μg/kg) for 7 days resulted in the morphological changes and increase in number of Iba-1+ microglia showing neuroinflammation in the adult mouse hippocampus. The LPS-induced activation of glial cells was significantly attenuated by i.p. pretreatment with Pls dissolved in corn oil. In addition, systemic injection of LPS induced Aβ1-16+ neurons in the hippocampus were also abolished by application of Pls. Finally, contents of Pls in the hippocampus decreased after LPS injection, and the reduction was suppressed by administration of Pls. These findings suggest an antiamyloidogenic effect of Pls, implicating a possible therapeutic application of Pls against AD.

UR - http://www.scopus.com/inward/record.url?scp=84864132951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864132951&partnerID=8YFLogxK

U2 - 10.1111/j.1749-6632.2012.06641.x

DO - 10.1111/j.1749-6632.2012.06641.x

M3 - Article

C2 - 22823439

AN - SCOPUS:84864132951

VL - 1262

SP - 85

EP - 92

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

IS - 1

ER -