Effects of PLGA reinforcement methods on the mechanical property of carbonate apatite foam

Girlie M. Munar, Melvin L. Munar, Kanji Tsuru, Kunio Ishikawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The purpose of this study was to improve the mechanical property of brittle carbonate apatite (CO3Ap) foam aimed as bone substitute material by reinforcement with poly(DL-lactide-co-glycolide) (PLGA). The CO3Ap foam was reinforced with PLGA by immersion and vacuum infiltration methods. Compressive strength of CO3Ap foam (12.0±4.9 kPa) increased after PLGA reinforcement by immersion (187.6±57.6 kPa) or vacuum infiltration (407.0±111.4 kPa). Scanning electron microscopic (SEM) observation showed a gapless PLGA and CO3Ap foam interface and larger amount of PLGA inside the hollow space of the strut when vacuum infiltration method was employed. In contrast a gap was observed at the PLGA and CO3Ap foam interface and less amount of PLGA inside the hollow space of the strut when immersion method was employed. Strong PLGA-CO3Ap foam interface and larger amount of PLGA inside the hollow space of the strut is therefore the key to higher mechanical property obtained for CO3Ap foam when vacuum infiltration was employed for PLGA reinforcement.

Original languageEnglish
Pages (from-to)1817-1825
Number of pages9
JournalBio-Medical Materials and Engineering
Volume24
Issue number5
DOIs
Publication statusPublished - Jan 1 2014

Fingerprint

Apatite
Foams
Carbonates
Reinforcement
Mechanical properties
Infiltration
Struts
Vacuum
Immersion
carboapatite
polylactic acid-polyglycolic acid copolymer
Compressive Strength
Bone Substitutes
Compressive strength
Polyglactin 910
Bone
Scanning
Electrons

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

Cite this

Effects of PLGA reinforcement methods on the mechanical property of carbonate apatite foam. / Munar, Girlie M.; Munar, Melvin L.; Tsuru, Kanji; Ishikawa, Kunio.

In: Bio-Medical Materials and Engineering, Vol. 24, No. 5, 01.01.2014, p. 1817-1825.

Research output: Contribution to journalArticle

Munar, Girlie M. ; Munar, Melvin L. ; Tsuru, Kanji ; Ishikawa, Kunio. / Effects of PLGA reinforcement methods on the mechanical property of carbonate apatite foam. In: Bio-Medical Materials and Engineering. 2014 ; Vol. 24, No. 5. pp. 1817-1825.
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