TY - JOUR
T1 - Effects of polychlorinated biphenyls on liver function and sexual characteristics in Japanese medaka (Oryzias latipes)
AU - Nakayama, Kei
AU - Sei, Naomi
AU - Handoh, Itsuki C.
AU - Shimasaki, Yohei
AU - Honjo, Tsuneo
AU - Oshima, Yuji
N1 - Funding Information:
We thank Prof. Yuko Wakamatsu, Nagoya University, Japan, for providing the FLF-II strain of medaka, and Dr. Margaret Murphy, City University of Hong Kong, for critical reading of this manuscript. This study was supported in part by the Special Coordination Funds for Promoting Science and by the “Global Center of Excellence Program” under the Ministry of Education, Culture, Sports, Science and Technology, the Government of Japan .
PY - 2011
Y1 - 2011
N2 - The effects of polychlorinated biphenyls (PCBs) on liver function and their differences between sexes were analyzed in Japanese medaka (Oryzias latipes) exposed to PCB126 or Kanechlor-400 (KC-400) using microarray. PCB exposure induced vitellogenin 1 expression in female medaka while suppressing choriogenin genes, which suggests that the effects of PCBs on estrogen-responsive genes do not occur directly through an estrogen receptor-mediated pathway. Reduction of androgen receptor alpha expression was also observed, and the gene expression pattern in PCB-exposed males changed to become more similar to that of females. Furthermore, changes in glycolysis-related genes indicate that PCB exposure might enhance glucose production via gluconeogenesis in the liver of medaka. Taken together, our results suggest that PCBs disrupt the endocrine system, especially androgen function, and may have the potential to cause demasculinizing effects. Additionally, induction of gluconeogenesis might be a response to maintain glucose levels consumed as a result of PCB exposures.
AB - The effects of polychlorinated biphenyls (PCBs) on liver function and their differences between sexes were analyzed in Japanese medaka (Oryzias latipes) exposed to PCB126 or Kanechlor-400 (KC-400) using microarray. PCB exposure induced vitellogenin 1 expression in female medaka while suppressing choriogenin genes, which suggests that the effects of PCBs on estrogen-responsive genes do not occur directly through an estrogen receptor-mediated pathway. Reduction of androgen receptor alpha expression was also observed, and the gene expression pattern in PCB-exposed males changed to become more similar to that of females. Furthermore, changes in glycolysis-related genes indicate that PCB exposure might enhance glucose production via gluconeogenesis in the liver of medaka. Taken together, our results suggest that PCBs disrupt the endocrine system, especially androgen function, and may have the potential to cause demasculinizing effects. Additionally, induction of gluconeogenesis might be a response to maintain glucose levels consumed as a result of PCB exposures.
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U2 - 10.1016/j.marpolbul.2011.01.015
DO - 10.1016/j.marpolbul.2011.01.015
M3 - Article
C2 - 21300381
AN - SCOPUS:79960341765
SN - 0025-326X
VL - 63
SP - 366
EP - 369
JO - Marine Pollution Bulletin
JF - Marine Pollution Bulletin
IS - 5-12
ER -