Effects of polychlorinated biphenyls on the monooxygenase systems in fetal livers of rats

K. Inoue; A. Takanaka; K. Mizokami; K. Fujimori; M. Sunouchi; Y. Kasuya; Y. Omori

doi:10.1016/0041-008X(81)90308-2

Effects of polychlorinated biphenyls on the monooxygenase systems in fetal livers of rats

K. Inoue, A. Takanaka, K. Mizokami, K. Fujimori, M. Sunouchi, Y. Kasuya, Y. Omori

Research output: Contribution to journal › Article › peer-review

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Abstract

The ontogenetic development of monooxygenase activities in fetal livers of rats and inducing effects of PCB on them were investigated. The following results were obtained. 1. The activities of monooxygenase systems in fetal livers of rats were detected on Days 17 to 22 of gestation, associated with NADPH-cytochrome c reductase activity and cytochrome P-450 content. All activities and content increased during the development. 2. These activities and content on Days 17 to 22 of gestation were induced by PCB given orally to pregnant rats. 3. The inducibilities of hexobarbital- and aminopyrine-metabolizing activities were very different from that of the benzo[α]pyrene-metabolizing activity. The results would indicate the existence of the different monooxygenase systems in the fetal liver.

Original language	English
Pages (from-to)	540-547
Number of pages	8
Journal	Toxicology and Applied Pharmacology
Volume	59
Issue number	3
DOIs	https://doi.org/10.1016/0041-008X(81)90308-2
Publication status	Published - Jul 1981
Externally published	Yes

All Science Journal Classification (ASJC) codes

Toxicology
Pharmacology

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10.1016/0041-008X(81)90308-2

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title = "Effects of polychlorinated biphenyls on the monooxygenase systems in fetal livers of rats",

abstract = "The ontogenetic development of monooxygenase activities in fetal livers of rats and inducing effects of PCB on them were investigated. The following results were obtained. 1. The activities of monooxygenase systems in fetal livers of rats were detected on Days 17 to 22 of gestation, associated with NADPH-cytochrome c reductase activity and cytochrome P-450 content. All activities and content increased during the development. 2. These activities and content on Days 17 to 22 of gestation were induced by PCB given orally to pregnant rats. 3. The inducibilities of hexobarbital- and aminopyrine-metabolizing activities were very different from that of the benzo[α]pyrene-metabolizing activity. The results would indicate the existence of the different monooxygenase systems in the fetal liver.",

author = "K. Inoue and A. Takanaka and K. Mizokami and K. Fujimori and M. Sunouchi and Y. Kasuya and Y. Omori",

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T1 - Effects of polychlorinated biphenyls on the monooxygenase systems in fetal livers of rats

AU - Inoue, K.

AU - Takanaka, A.

AU - Mizokami, K.

AU - Fujimori, K.

AU - Sunouchi, M.

AU - Kasuya, Y.

AU - Omori, Y.

PY - 1981/7

Y1 - 1981/7

N2 - The ontogenetic development of monooxygenase activities in fetal livers of rats and inducing effects of PCB on them were investigated. The following results were obtained. 1. The activities of monooxygenase systems in fetal livers of rats were detected on Days 17 to 22 of gestation, associated with NADPH-cytochrome c reductase activity and cytochrome P-450 content. All activities and content increased during the development. 2. These activities and content on Days 17 to 22 of gestation were induced by PCB given orally to pregnant rats. 3. The inducibilities of hexobarbital- and aminopyrine-metabolizing activities were very different from that of the benzo[α]pyrene-metabolizing activity. The results would indicate the existence of the different monooxygenase systems in the fetal liver.

AB - The ontogenetic development of monooxygenase activities in fetal livers of rats and inducing effects of PCB on them were investigated. The following results were obtained. 1. The activities of monooxygenase systems in fetal livers of rats were detected on Days 17 to 22 of gestation, associated with NADPH-cytochrome c reductase activity and cytochrome P-450 content. All activities and content increased during the development. 2. These activities and content on Days 17 to 22 of gestation were induced by PCB given orally to pregnant rats. 3. The inducibilities of hexobarbital- and aminopyrine-metabolizing activities were very different from that of the benzo[α]pyrene-metabolizing activity. The results would indicate the existence of the different monooxygenase systems in the fetal liver.

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Effects of polychlorinated biphenyls on the monooxygenase systems in fetal livers of rats

Abstract

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