Effects of polychlorinated biphenyls on the monooxygenase systems in fetal livers of rats

K. Inoue, A. Takanaka, K. Mizokami, K. Fujimori, M. Sunouchi, Y. Kasuya, Y. Omori

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The ontogenetic development of monooxygenase activities in fetal livers of rats and inducing effects of PCB on them were investigated. The following results were obtained. 1. The activities of monooxygenase systems in fetal livers of rats were detected on Days 17 to 22 of gestation, associated with NADPH-cytochrome c reductase activity and cytochrome P-450 content. All activities and content increased during the development. 2. These activities and content on Days 17 to 22 of gestation were induced by PCB given orally to pregnant rats. 3. The inducibilities of hexobarbital- and aminopyrine-metabolizing activities were very different from that of the benzo[α]pyrene-metabolizing activity. The results would indicate the existence of the different monooxygenase systems in the fetal liver.

Original languageEnglish
Pages (from-to)540-547
Number of pages8
JournalToxicology and Applied Pharmacology
Volume59
Issue number3
DOIs
Publication statusPublished - Jul 1981
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology

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