Effects of polychlorinated biphenyls on the monooxygenase systems in fetal livers of rats

K. Inoue, A. Takanaka, K. Mizokami, K. Fujimori, M. Sunouchi, Y. Kasuya, Y. Omori

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The ontogenetic development of monooxygenase activities in fetal livers of rats and inducing effects of PCB on them were investigated. The following results were obtained. 1. The activities of monooxygenase systems in fetal livers of rats were detected on Days 17 to 22 of gestation, associated with NADPH-cytochrome c reductase activity and cytochrome P-450 content. All activities and content increased during the development. 2. These activities and content on Days 17 to 22 of gestation were induced by PCB given orally to pregnant rats. 3. The inducibilities of hexobarbital- and aminopyrine-metabolizing activities were very different from that of the benzo[α]pyrene-metabolizing activity. The results would indicate the existence of the different monooxygenase systems in the fetal liver.

Original languageEnglish
Pages (from-to)540-547
Number of pages8
JournalToxicology and Applied Pharmacology
Volume59
Issue number3
DOIs
Publication statusPublished - Jul 1981
Externally publishedYes

Fingerprint

Polychlorinated Biphenyls
Mixed Function Oxygenases
Liver
Rats
Hexobarbital
Aminopyrine
Fetal Movement
Pregnancy
NADPH-Ferrihemoprotein Reductase
Cytochrome P-450 Enzyme System

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology

Cite this

Effects of polychlorinated biphenyls on the monooxygenase systems in fetal livers of rats. / Inoue, K.; Takanaka, A.; Mizokami, K.; Fujimori, K.; Sunouchi, M.; Kasuya, Y.; Omori, Y.

In: Toxicology and Applied Pharmacology, Vol. 59, No. 3, 07.1981, p. 540-547.

Research output: Contribution to journalArticle

Inoue, K. ; Takanaka, A. ; Mizokami, K. ; Fujimori, K. ; Sunouchi, M. ; Kasuya, Y. ; Omori, Y. / Effects of polychlorinated biphenyls on the monooxygenase systems in fetal livers of rats. In: Toxicology and Applied Pharmacology. 1981 ; Vol. 59, No. 3. pp. 540-547.
@article{ff0ec7b0220f48db94e3d90841f66b61,
title = "Effects of polychlorinated biphenyls on the monooxygenase systems in fetal livers of rats",
abstract = "The ontogenetic development of monooxygenase activities in fetal livers of rats and inducing effects of PCB on them were investigated. The following results were obtained. 1. The activities of monooxygenase systems in fetal livers of rats were detected on Days 17 to 22 of gestation, associated with NADPH-cytochrome c reductase activity and cytochrome P-450 content. All activities and content increased during the development. 2. These activities and content on Days 17 to 22 of gestation were induced by PCB given orally to pregnant rats. 3. The inducibilities of hexobarbital- and aminopyrine-metabolizing activities were very different from that of the benzo[α]pyrene-metabolizing activity. The results would indicate the existence of the different monooxygenase systems in the fetal liver.",
author = "K. Inoue and A. Takanaka and K. Mizokami and K. Fujimori and M. Sunouchi and Y. Kasuya and Y. Omori",
year = "1981",
month = "7",
doi = "10.1016/0041-008X(81)90308-2",
language = "English",
volume = "59",
pages = "540--547",
journal = "Toxicology and Applied Pharmacology",
issn = "0041-008X",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Effects of polychlorinated biphenyls on the monooxygenase systems in fetal livers of rats

AU - Inoue, K.

AU - Takanaka, A.

AU - Mizokami, K.

AU - Fujimori, K.

AU - Sunouchi, M.

AU - Kasuya, Y.

AU - Omori, Y.

PY - 1981/7

Y1 - 1981/7

N2 - The ontogenetic development of monooxygenase activities in fetal livers of rats and inducing effects of PCB on them were investigated. The following results were obtained. 1. The activities of monooxygenase systems in fetal livers of rats were detected on Days 17 to 22 of gestation, associated with NADPH-cytochrome c reductase activity and cytochrome P-450 content. All activities and content increased during the development. 2. These activities and content on Days 17 to 22 of gestation were induced by PCB given orally to pregnant rats. 3. The inducibilities of hexobarbital- and aminopyrine-metabolizing activities were very different from that of the benzo[α]pyrene-metabolizing activity. The results would indicate the existence of the different monooxygenase systems in the fetal liver.

AB - The ontogenetic development of monooxygenase activities in fetal livers of rats and inducing effects of PCB on them were investigated. The following results were obtained. 1. The activities of monooxygenase systems in fetal livers of rats were detected on Days 17 to 22 of gestation, associated with NADPH-cytochrome c reductase activity and cytochrome P-450 content. All activities and content increased during the development. 2. These activities and content on Days 17 to 22 of gestation were induced by PCB given orally to pregnant rats. 3. The inducibilities of hexobarbital- and aminopyrine-metabolizing activities were very different from that of the benzo[α]pyrene-metabolizing activity. The results would indicate the existence of the different monooxygenase systems in the fetal liver.

UR - http://www.scopus.com/inward/record.url?scp=0019455112&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019455112&partnerID=8YFLogxK

U2 - 10.1016/0041-008X(81)90308-2

DO - 10.1016/0041-008X(81)90308-2

M3 - Article

C2 - 6791309

AN - SCOPUS:0019455112

VL - 59

SP - 540

EP - 547

JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

SN - 0041-008X

IS - 3

ER -