Effects of preceding interferon therapy on outcome after surgery for hepatitis C virus-related hepatocellular carcinoma

Yoshito Tomimaru, Hiroaki Nagano, Hidetoshi Eguchi, Shogo Kobayashi, Shigeru Marubashi, Hiroshi Wada, Masahiro Tanemura, Koji Umeshita, Naoki Hiramatsu, Tetsuo Takehara, Yuichiro Doki, Masaki Mori

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5 Citations (Scopus)

Abstract

Background and Objectives: Interferon (IFN) can eradicate hepatitis C virus (HCV)-RNA from serum and hepatic tissue, and suppress the development of hepatocellular carcinoma (HCC). Despite such effectiveness, HCC develops even in HCV patients successfully treated with IFN therapy. Methods: HCV-related HCC patients who underwent curative hepatectomy for HCC were divided into three groups according to preceding IFN for HCV infection therapy and the therapeutic effect: responders group (n=23), non-responders group (n=46), and no-IFN group (n=215). Postoperative outcome was retrospectively examined in the three groups. Results: AST and ALT were significantly lower in responders group than non-responders group (P<0.001, P=0.001) and no-IFN group (P=0.001, P=0.002). Platelet count was significantly higher in responders group than other groups (P=0.008, P=0.001). The percentage of cirrhotic patients in responders group was significantly lower than other groups (P=0.017, P=0.014). Multivariate analysis identified preceding IFN therapy to be associated with disease-free survival at marginal significance (P=0.086), and as a significant independent factor for overall survival (P=0.042). Conclusions: Preceding IFN therapy for HCV infection improves postoperative outcome in HCV-related HCC patients treated successfully with IFN.

Original languageEnglish
Pages (from-to)308-314
Number of pages7
JournalJournal of Surgical Oncology
Volume102
Issue number4
DOIs
Publication statusPublished - Sep 15 2010

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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    Tomimaru, Y., Nagano, H., Eguchi, H., Kobayashi, S., Marubashi, S., Wada, H., Tanemura, M., Umeshita, K., Hiramatsu, N., Takehara, T., Doki, Y., & Mori, M. (2010). Effects of preceding interferon therapy on outcome after surgery for hepatitis C virus-related hepatocellular carcinoma. Journal of Surgical Oncology, 102(4), 308-314. https://doi.org/10.1002/jso.21633