TY - JOUR
T1 - Effects of probiotic Lactobacillus salivarius WB21 on halitosis and oral health
T2 - An open-label pilot trial
AU - Iwamoto, Tomoyuki
AU - Suzuki, Nao
AU - Tanabe, Kazunari
AU - Takeshita, Toru
AU - Hirofuji, Takao
N1 - Funding Information:
This study was supported by Grants-in-Aid for Scientific Research (C) 20592249 (to M.Y.) and 20592444 (to T.N.), Grants-in-Aid for Young Scientists 21890187 (to T.T.), and Grants-in-Aid for Scientific Research (Strategic Research Promotion) from the Ministry of Education, Culture, Sports, Technology and Science , Japan, and a research grant from the Mitsui Sumitomo Insurance Welfare Foundation .
PY - 2010
Y1 - 2010
N2 - Objective: The objective of this study was to evaluate whether oral administration of lactobacilli alters the degree of halitosis and clinical conditions associated with halitosis. Study design: Twenty patients with genuine halitosis were given 2.0 × 109 Lactobacillus salivarius WB21 and xylitol in tablet form daily. Oral malodor and clinical parameters were evaluated at the same time of day for each patient after 2 and 4 weeks. Results: All 20 patients were positive for L. salivarius DNA in their saliva at 2 weeks, although 12 patients were negative for this organism at baseline. Oral malodor parameters significantly decreased at 2 weeks in the subjects with physiologic halitosis. The scores of an organoleptic test and bleeding on probing significantly decreased at 4 weeks in the subjects with oral pathologic halitosis. Conclusions: Oral administration of probiotic lactobacilli primarily improved physiologic halitosis and also showed beneficial effects on bleeding on probing from the periodontal pocket.
AB - Objective: The objective of this study was to evaluate whether oral administration of lactobacilli alters the degree of halitosis and clinical conditions associated with halitosis. Study design: Twenty patients with genuine halitosis were given 2.0 × 109 Lactobacillus salivarius WB21 and xylitol in tablet form daily. Oral malodor and clinical parameters were evaluated at the same time of day for each patient after 2 and 4 weeks. Results: All 20 patients were positive for L. salivarius DNA in their saliva at 2 weeks, although 12 patients were negative for this organism at baseline. Oral malodor parameters significantly decreased at 2 weeks in the subjects with physiologic halitosis. The scores of an organoleptic test and bleeding on probing significantly decreased at 4 weeks in the subjects with oral pathologic halitosis. Conclusions: Oral administration of probiotic lactobacilli primarily improved physiologic halitosis and also showed beneficial effects on bleeding on probing from the periodontal pocket.
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U2 - 10.1016/j.tripleo.2010.03.032
DO - 10.1016/j.tripleo.2010.03.032
M3 - Article
C2 - 20659698
AN - SCOPUS:77955383448
SN - 2212-4403
VL - 110
SP - 201
EP - 208
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
IS - 2
ER -