Effects of Sesamin and α-Tocopherol, Individually or in Combination, on the Polyunsaturated Fatty Acid Metabolism, Chemical Mediator Production, and Immunoglobulin Levels in Sprague-Dawley Rats

Jiongyan Gu, Yoko Wakizono, Akira Tsujita, Beong ou Lim, Michiko Nonaka, Koji Yamada, Michihiro Sugano

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Feeding sesamin and α-tocopherol in combination, both at the 0.5% dietary level, to Sprague-Dawley rats for 3 weeks resulted in a trend toward decreasing the proportion of 20:4n-6 and 22:5n-6 and increasing that of 18:2n-6 in phosphatidylcholine from various tissues, suggesting interference with the metabolism of linoleic acid. This dietary manipulation significantly reduced the production of leukotriene C 4 in the lung, the splenic production of leukotriene B 4 , and reduction of the plasma histamine level. Simultaneous administration of sesamin and α-tocopherol signiticantly increased the production of IgA, IgG, and IgM by mesenteric lymph node lymphocytes, while the IgE level tended to be reduced. These effects were not necessarily apparent by feeding these compounds separately. Thus, sesamin and α-tocopherol in combination would be effective for regulating the eicosanoid production and modifying the immune function.

Original languageEnglish
Pages (from-to)2198-2202
Number of pages5
JournalBioscience, biotechnology, and biochemistry
Volume59
Issue number12
DOIs
Publication statusPublished - Jan 1 1995

Fingerprint

Tocopherols
Unsaturated Fatty Acids
Metabolism
Sprague Dawley Rats
Immunoglobulins
Rats
Leukotriene C4
Leukotriene B4
Eicosanoids
Linoleic Acid
Phosphatidylcholines
Immunoglobulin A
Immunoglobulin E
Histamine
Immunoglobulin M
Lymphocytes
Immunoglobulin G
Lymph Nodes
Lung
Tissue

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Effects of Sesamin and α-Tocopherol, Individually or in Combination, on the Polyunsaturated Fatty Acid Metabolism, Chemical Mediator Production, and Immunoglobulin Levels in Sprague-Dawley Rats. / Gu, Jiongyan; Wakizono, Yoko; Tsujita, Akira; Lim, Beong ou; Nonaka, Michiko; Yamada, Koji; Sugano, Michihiro.

In: Bioscience, biotechnology, and biochemistry, Vol. 59, No. 12, 01.01.1995, p. 2198-2202.

Research output: Contribution to journalArticle

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