Effects of Sesamin and α-Tocopherol, Individually or in Combination, on the Polyunsaturated Fatty Acid Metabolism, Chemical Mediator Production, and Immunoglobulin Levels in Sprague-Dawley Rats

Jiongyan Gu, Yoko Wakizono, Akira Tsujita, Beong ou Lim, Michiko Nonaka, Koji Yamada, Michihiro Sugano

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Feeding sesamin and α-tocopherol in combination, both at the 0.5% dietary level, to Sprague-Dawley rats for 3 weeks resulted in a trend toward decreasing the proportion of 20:4n-6 and 22:5n-6 and increasing that of 18:2n-6 in phosphatidylcholine from various tissues, suggesting interference with the metabolism of linoleic acid. This dietary manipulation significantly reduced the production of leukotriene C 4 in the lung, the splenic production of leukotriene B 4 , and reduction of the plasma histamine level. Simultaneous administration of sesamin and α-tocopherol signiticantly increased the production of IgA, IgG, and IgM by mesenteric lymph node lymphocytes, while the IgE level tended to be reduced. These effects were not necessarily apparent by feeding these compounds separately. Thus, sesamin and α-tocopherol in combination would be effective for regulating the eicosanoid production and modifying the immune function.

Original languageEnglish
Pages (from-to)2198-2202
Number of pages5
JournalBioscience, biotechnology, and biochemistry
Volume59
Issue number12
DOIs
Publication statusPublished - Jan 1 1995

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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