Effects of sesamin and α-tocopherol on the production of chemical mediators and immunoglobulins in brown-norway rats

Jiong Yan Gu, Michiko Nonaka, Koji Yamada, Kazunari Yoshimura, Mikako Takasugi, Yuji Ito, Michihiro Sugano

Research output: Contribution to journalArticle

Abstract

This study investigated the effects of sesamin and α-tocopherol on eicosanoid production and immune function in the rat. Male Brown-Norway rats, 4 weeks of age, were given either control, 0.5% sesamin, 0.5% α-tocopherol, or 0.5% sesamin plus 0.5% α-tocopherol diets for 3 weeks. When sesamin and tocopherol were given together, the proportion of 20: 4n-6 phosphatidylcholine (PC) was significantly lowered in liver and lung, while that of 18: 2n-6 and 20: 3n-6 was significantly increased in liver. Simultaneous administration of these compounds significantly reduced the production by the lung of leukotriene C4 (LTC4), but there was no effect on the splenic LTC4 production and the plasma prostaglandin E2 concentration. Sesamin and tocopherol, either separately or in combination, significantly reduced both the proportion of splenic CD4+ and CD8+ T cells, but the change in the CD4+/CD8+ ratio was not significant. The effects of sesamin and tocopherol feeding on serum levels of IgA, IgE, and IgG were not so marked, but tocopherol significantly decreased the serum IgM level. These results suggest that the feeding of sesamin and tocopherol suppress LTC4 production through the decrease in the arachidonic acid level in lung PC.

Original languageEnglish
Pages (from-to)1855-1858
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume58
Issue number10
DOIs
Publication statusPublished - Jan 1 1994

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Effects of sesamin and α-tocopherol on the production of chemical mediators and immunoglobulins in brown-norway rats'. Together they form a unique fingerprint.

Cite this