Effects of sevoflurane and isoflurane anesthesia on arterial ketone body ratio and liver function

T. Nishiyama, T. Yokoyama, K. Hanaoka

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Abstract

Background: The purpose of this study was to compare the effect on arterial ketone body ratio (AKBR), which indicates hepatic mitochondrial energy charge in relation to hepatic blood flow, and liver function test (serum levels of liver enzymes) between sevoflurane and isoflurane anesthesia. Methods: Serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBil), alkaline phosphatase (ALP), γ-glutamyl transpeptidase (GTP), and lactate dehydrogenase (LDH) were measured before and 1, 2, 3, 7, and 14 days after anesthesia in each of 60 patients receiving either sevoflurane or isoflurane anesthesia for neurosurgery (tumor resection). In 13 patients of both groups, arterial concentrations of acetoacetate and 3-hydroxybutyrate were also measured before, during and after (up to 12 h) anesthesia and the AKBR was calculated. Results: AST, ALT and GTP increased, peaking 7 days after anesthesia, especially in the isoflurane group. There was a significantly greater number of patients with abnormal AST and ALT values in the isoflurane group than in the sevoflurane group. The increase of TBil had its peak I day after anesthesia in both groups. AKBR decreased after anesthesia induction and recovered to the control value 12 h after anesthesia in both groups. There was no difference between the two anesthetic groups in AKBR. Conclusion: Isoflurane induced an elevation of serum levels of liver enzymes more frequently than did sevoflurane 3 to 14 days after anesthesia, while AKBR until 12 h after anesthesia did not show any significant difference between sevoflurane and isoflurane anesthesia.

Original languageEnglish
Pages (from-to)347-351
Number of pages5
JournalActa Anaesthesiologica Scandinavica
Volume43
Issue number3
DOIs
Publication statusPublished - Mar 11 1999

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Ketone Bodies
Isoflurane
Anesthesia
Liver
Aspartate Aminotransferases
Alanine Transaminase
gamma-Glutamyltransferase
Bilirubin
sevoflurane
Serum
3-Hydroxybutyric Acid
Liver Function Tests
Neurosurgery
Enzymes
L-Lactate Dehydrogenase
Alkaline Phosphatase
Anesthetics

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

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Effects of sevoflurane and isoflurane anesthesia on arterial ketone body ratio and liver function. / Nishiyama, T.; Yokoyama, T.; Hanaoka, K.

In: Acta Anaesthesiologica Scandinavica, Vol. 43, No. 3, 11.03.1999, p. 347-351.

Research output: Contribution to journalArticle

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