TY - JOUR
T1 - Effects of simultaneous administration of tributyltin (tbt) and p, p ’ -dde on female offspring of wistar rats
AU - Makita, Yuji
AU - Tanaka, Akiyo
AU - Omura, Minoru
AU - Ogata, Rika
N1 - Funding Information:
Accepted 6 June 2003. We thank Y. Hirose and A. Tawara for technical assistance. This study was partly supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, Japan (grants 10470096 and 12670321). Address correspondence to Y. Makita, MD, PhD, Department of Hygiene, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. E-mail: ymakita@eisei.med.kyushu-u.ac.jp
PY - 2003
Y1 - 2003
N2 - P, p ’ -DDE (DDE) and tributyltin (TBT) occur globally and in Japan were shown to bioaccumulate in marine products, thus serving as a source of contamination in the mammalian food chain. Consequently, fetuses and neonates, through maternal ingestion, may be exposed to DDE and TBT. Therefore, the effects of combined DDE and TBT were investigated in female Wistar rat offspring of dams ingesting these two contaminants. In this study, TBT suppressed the growth of female offspring and delayed eye opening. However, both growth retardation and delayed eye opening produced by TBT failed to occur in the presence of DDE. These results indicated that TBT or DDE affected the development of female rat offspring following maternal exposure and simultaneous administration of DDE prevented some of the observed effects of TBT through a mechanism that remains to be elucidated.
AB - P, p ’ -DDE (DDE) and tributyltin (TBT) occur globally and in Japan were shown to bioaccumulate in marine products, thus serving as a source of contamination in the mammalian food chain. Consequently, fetuses and neonates, through maternal ingestion, may be exposed to DDE and TBT. Therefore, the effects of combined DDE and TBT were investigated in female Wistar rat offspring of dams ingesting these two contaminants. In this study, TBT suppressed the growth of female offspring and delayed eye opening. However, both growth retardation and delayed eye opening produced by TBT failed to occur in the presence of DDE. These results indicated that TBT or DDE affected the development of female rat offspring following maternal exposure and simultaneous administration of DDE prevented some of the observed effects of TBT through a mechanism that remains to be elucidated.
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U2 - 10.1080/716100642
DO - 10.1080/716100642
M3 - Article
C2 - 14630525
AN - SCOPUS:0347419315
SN - 1528-7394
VL - 66
SP - 2337
EP - 2347
JO - Journal of Toxicology and Environmental Health - Part A: Current Issues
JF - Journal of Toxicology and Environmental Health - Part A: Current Issues
IS - 24
ER -
